Effects of sulfuric acid and nitrogen dioxide on airway responsiveness of the guinea pig

Journal Article · Thu Jan 01 04:00:00 EST 1981 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398109530048· OSTI ID:6445948

Silbaugh, S A; Mauderly, J L; Macken, C A

Hartley guinea pigs were exposed for 1 h to either NO/sub 2/ gas or H/sub 2/SO/sub 4/ aerosol and examined for changes in airway responsiveness to inhaled histamine. Concentrations ranged from 7 to 146 ppm NO/sub 2/ and 4 to 40 mg/m/sup 3/ H/sub 2/SO/sub 4/. One group of animals exposed to filtered air served as controls. Histamine challenges were performed on unanesthetized animals 2 h before pollutant or air exposure (baseline) and 10 min and 2 and 19 h after exposure, and the magnitude of the increase was directly dependent on the NO/sub 2/ concentration. Most of the NO/sub 2/-exposed animals demonstrated a dramatic return toward baseline values by 2 h after exposure; however, several animals had not returned to baseline by 19 h after exposure. Some animals exposed to H/sub 2/SO/sub 4/ developed severe labored breathing during exposure, and major increases in histamine sensitivity were observed only in those animals. These results suggest that both NO/sub 2/ and H/sub 2/SO/sub 4/ alter airway sensitivity to histamine, but apparently by different mechanisms. Changes produced by NO/sub 2/ exposures appeared primarily concentration-dependent, while changes produced by H/sub 2/SO/sub 4/ exposures appeared related to dyspnea developed during exposure.

• Research Organization: Inhalation Toxicology Research Inst., Albuquerque, NM
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 6445948
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 8:1-2; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
AMINES
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BREATH
CHALCOGENIDES
DOSE-RESPONSE RELATIONSHIPS
EPIDEMIOLOGY
GUINEA PIGS
HETEROCYCLIC COMPOUNDS
HISTAMINE
HYDROGEN COMPOUNDS
IMIDAZOLES
INHALATION
INORGANIC ACIDS
INTAKE
MAMMALS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RODENTS
SENSITIVITY
SULFURIC ACID
VERTEBRATES