Sequential Two-Electron Oxidation of Ubiquinol by the Cytochrome bc1 Complex
Conference
·
OSTI ID:877039
The cytochrome bc complexes are critical components of electron transfer chains in mitochondria, chloroplasts and many bacteria. They act by coupling the oxidation of quinol species to vectoral proton pumping across bioenergetic membranes, contributing to the proton motive force required for ATP synthesis. Certain physiological conditions and inhibitors of the mitochondrial cytochrome bc1 complex can induce these complexes to generate superoxide (Muller 2002), making them important subjects for oxidative stress research.
- Research Organization:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 877039
- Report Number(s):
- PNNL-SA-45295; 2358a; KP1704020
- Country of Publication:
- United States
- Language:
- English
Similar Records
Kinetic Steering of Quinol Oxidation by ‘Proton Stripping’ at the Cytochrome bc1 Complex Qo Site
A Biomimetic Approach to Discrimination Between Sequential and Concerted Models for the Oxidation of Ubiquinol at the Qo site of the Cyt bc1 Complex
Similar Transition States Mediate the Q-cycle and Superoxide Production by the Cytochrome bc1 Complex
Conference
·
Fri May 13 00:00:00 EDT 2005
·
OSTI ID:877040
A Biomimetic Approach to Discrimination Between Sequential and Concerted Models for the Oxidation of Ubiquinol at the Qo site of the Cyt bc1 Complex
Conference
·
Mon Sep 26 00:00:00 EDT 2005
·
OSTI ID:877038
Similar Transition States Mediate the Q-cycle and Superoxide Production by the Cytochrome bc1 Complex
Journal Article
·
Thu Dec 14 23:00:00 EST 2006
· Journal of Biological Chemistry, 281(50):38459-38465
·
OSTI ID:897679