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Oncoprotein protein kinase

Patent ·
OSTI ID:875023
 [1];  [1];  [2];  [3];  [4]
  1. San Diego, CA
  2. La Jolla, CA
  3. Princeton, MA
  4. Shrewsbury, MA
+ Show Author Affiliations
An isolated polypeptide (JNK) characterized by having a molecular weight of 46kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.
Research Organization:
University of California
DOE Contract Number:
FG03-86ER60429
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
US 6514745
Application Number:
08/220,602
OSTI ID:
875023
Country of Publication:
United States
Language:
English

References (4)

Phosphorylation of c-jun mediated by MAP kinases journal October 1991
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. journal November 1993
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control journal July 1990
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF journal May 1991

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Related Subjects

/435/999/
46kd
activation
activity
affects
ap-1
c-jun
characterized
detection
determined
domain
expression
isolated
isolated polypeptide
jnk
kinase
kinase activity
method
molecular
molecular weight
n-terminal
oncoprotein
oncoprotein protein
phosphorylates
phosphorylating
polynucleotide
polynucleotide sequences
polypeptide
protein
protein kinase
provided
reducing
reducing sds-page
sds-page
sequences
serine
sites
threonine
threonine kinase
weight