1-deoxy-D-xylulose-5-phosphate reductoisomerases, and methods of use

Croteau, Rodney B; Lange, Bernd M

1-deoxy-D-xylulose-5-phosphate reductoisomerases, and methods of use

Patent · Mon Dec 31 23:00:00 EST 2001

OSTI ID:874583

Croteau, Rodney B ^[1]; Lange, Bernd M ^[1]

Pullman, WA

The present invention relates to isolated DNA sequences which code for the expression of plant 1-deoxy-D-xylulose-5-phosphate reductoisomerase protein, such as the sequence presented in SEQ ID NO:1 which encodes a 1-deoxy-D-xylulose-5-phosphate reductoisomerase protein from peppermint (Mentha x piperita). Additionally, the present invention relates to isolated plant 1-deoxy-D-xylulose-5-phosphate reductoisomerase protein. In other aspects, the present invention is directed to replicable recombinant cloning vehicles comprising a nucleic acid sequence which codes for a plant 1-deoxy-D-xylulose-5-phosphate reductoisomerase, to modified host cells transformed, transfected, infected and/or injected with a recombinant cloning vehicle and/or DNA sequence of the invention.

Research Organization:: Washington State University Research Foundation (Pullman, WA)

DOE Contract Number:: FG03-96ER20212

Assignee:: Washington State University Research Foundation (Pullman, WA)

Patent Number(s):: US 6420159

Application Number:: 09/874562

OSTI ID:: 874583

Country of Publication:: United States

Language:: English

References (7)

Direct formation of 2-C-methyl-d-erythritol 4-phosphate from 1-deoxy-d-xylulose 5-phosphate by 1-deoxy-d-xylulose 5-phosphate reductoisomerase, a new enzyme in the non-mevalonate pathway to isopentenyl diphosphate Kuzuyama, Tomohisa; Takahashi, Shunji; Watanabe, Hiroyuki Tetrahedron Letters, Vol. 39, Issue 25 https://doi.org/10.1016/S0040-4039(98)00802-8	journal	June 1998
Fosmidomycin, a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis Kuzuyama, Tomohisa; Shimizu, Tomohiro; Takahashi, Shunji Tetrahedron Letters, Vol. 39, Issue 43 https://doi.org/10.1016/S0040-4039(98)01755-9	journal	October 1998
Reduction in the rate of DNA reassociation by sequence divergence Bonner, Tom I.; Brenner, Don J.; Neufeld, Berney R. Journal of Molecular Biology, Vol. 81, Issue 2 https://doi.org/10.1016/0022-2836(73)90184-8	journal	December 1973
Isoprenoid Biosynthesis via a Mevalonate-Independent Pathway in Plants: Cloning and Heterologous Expression of 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase from Peppermint Lange, B. Markus; Croteau, Rodney Archives of Biochemistry and Biophysics, Vol. 365, Issue 1 https://doi.org/10.1006/abbi.1999.1168	journal	May 1999
Cloning and heterologous expression of a cDNA encoding 1-deoxy- D -xylulose-5-phosphate reductoisomerase of Arabidopsis thaliana ¹ Schwender, Jörg; Müller, Christian; Zeidler, Johannes FEBS Letters, Vol. 455, Issue 1-2 https://doi.org/10.1016/S0014-5793(99)00849-2	journal	July 1999
A General Method for the Isolation of rna Complementary to dna Bolton, E. T.; McCarthy, B. J. Proceedings of the National Academy of Sciences, Vol. 48, Issue 8 https://doi.org/10.1073/pnas.48.8.1390	journal	August 1962
A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis Takahashi, S.; Kuzuyama, T.; Watanabe, H. Proceedings of the National Academy of Sciences, Vol. 95, Issue 17 https://doi.org/10.1073/pnas.95.17.9879	journal	August 1998

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cells
cloning
cloning vehicle
code
codes
comprising
directed
dna
encodes
expression
host
infected
injected
isolated
mentha
methods
modified
no1
nucleic
nucleic acid
peppermint
piperita
plant
protein
recombinant
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reductoisomerases
relates
replicable
seq
sequence
sequences
transfected
transformed
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1-deoxy-D-xylulose-5-phosphate reductoisomerases, and methods of use

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