Biochip scanner device

Patent · Sun Dec 31 23:00:00 EST 2000

OSTI ID:874166

Perov, Alexander ^[1]; Belgovskiy, Alexander I ^[2]; Mirzabekov, Andrei D ^[3]

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1. Troitsk, RU
2. Mayfield Heights, OH
3. Darien, IL

A biochip scanner device used to detect and acquire fluorescence signal data from biological microchips or biochips and method of use are provided. The biochip scanner device includes a laser for emitting a laser beam. A modulator, such as an optical chopper modulates the laser beam. A scanning head receives the modulated laser beam and a scanning mechanics coupled to the scanning head moves the scanning head relative to the biochip. An optical fiber delivers the modulated laser beam to the scanning head. The scanning head collects the fluorescence light from the biochip, launches it into the same optical fiber, which delivers the fluorescence into a photodetector, such as a photodiode. The biochip scanner device is used in a row scanning method to scan selected rows of the biochip with the laser beam size matching the size of the immobilization site.

• Research Organization: Argonne National Laboratory (ANL), Argonne, IL
• DOE Contract Number: W-31109-ENG-38
• Assignee: The University of Chicago (Chicago, IL)
• Patent Number(s): US 6329661
• OSTI ID: 874166
• Country of Publication: United States
• Language: English

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acquire
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biological
chopper
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coupled
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delivers
detect
device
emitting
fiber
fluorescence
head
immobilization
laser
laser beam
launches
light
matching
mechanics
method
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modulated
modulates
modulator
moves
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receives
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scanning
selected
signal
site
size