Biochip scanner device

Patent · Mon Jan 01 00:00:00 EST 2001

OSTI ID:874166

Perov, Alexander ^[1]; Belgovskiy, Alexander I ^[2]; Mirzabekov, Andrei D ^[3]

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1. Troitsk, RU
2. Mayfield Heights, OH
3. Darien, IL

A biochip scanner device used to detect and acquire fluorescence signal data from biological microchips or biochips and method of use are provided. The biochip scanner device includes a laser for emitting a laser beam. A modulator, such as an optical chopper modulates the laser beam. A scanning head receives the modulated laser beam and a scanning mechanics coupled to the scanning head moves the scanning head relative to the biochip. An optical fiber delivers the modulated laser beam to the scanning head. The scanning head collects the fluorescence light from the biochip, launches it into the same optical fiber, which delivers the fluorescence into a photodetector, such as a photodiode. The biochip scanner device is used in a row scanning method to scan selected rows of the biochip with the laser beam size matching the size of the immobilization site.

• Research Organization: Argonne National Laboratory (ANL), Argonne, IL (United States)
• DOE Contract Number: W-31109-ENG-38
• Assignee: The University of Chicago (Chicago, IL)
• Patent Number(s): US 6329661
• OSTI ID: 874166
• Country of Publication: United States
• Language: English

Related Subjects

biochip
scanner
device
detect
acquire
fluorescence
signal
data
biological
microchips
biochips
method
provided
laser
emitting
beam
modulator
optical
chopper
modulates
scanning
head
receives
modulated
mechanics
coupled
moves
fiber
delivers
collects
light
launches
photodetector
photodiode
row
scan
selected
rows
size
matching
immobilization
site
laser beam
optical fiber
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