Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry

Yeung, Edward S; Chang, Yu-chen

Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry

Patent · Thu Dec 31 23:00:00 EST 1998

OSTI ID:872359

Yeung, Edward S ^[1]; Chang, Yu-chen ^[2]

Ames, IA
Taichung Hsien, TW

The present invention provides a laser-induced vaporization and ionization interface for directly coupling microscale separation processes to a mass spectrometer. Vaporization and ionization of the separated analytes are facilitated by the addition of a light-absorbing component to the separation buffer or solvent.

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Research Organization:: Ames Laboratory (AMES), Ames, IA; Iowa State University, Ames, IA (US)

DOE Contract Number:: W-7405-ENG-82

Assignee:: Iowa State University Research Foundation, Inc. (Ames, IA)

Patent Number(s):: US 5917185

Application Number:: 08/882,855

OSTI ID:: 872359

Country of Publication:: United States

Language:: English

References (22)

Capillary electrophoresis Schwer, Ch.; Kenndler, E. Chromatographia, Vol. 30, Issue 9-10 https://doi.org/10.1007/BF02269803	journal	November 1990
Pulsed sample introduction interface for combining flow injection analysis with multiphoton ionization time-of-flight mass spectrometry Wang, Alan P. L.; Li, Liang. Analytical Chemistry, Vol. 64, Issue 7 https://doi.org/10.1021/ac00031a012	journal	April 1992
Aerosol MALDI with a Reflectron Time-of-Flight Mass Spectrometer Fei, Xun; Wei, Gang; Murray, Kermit K. Analytical Chemistry, Vol. 68, Issue 7 https://doi.org/10.1021/ac950913p	journal	January 1996
Continuous-flow matrix-assisted laser desorption ionization mass spectrometry Li, Liang.; Wang, Alan P. L.; Coulson, Larry D. Analytical Chemistry, Vol. 65, Issue 4 https://doi.org/10.1021/ac00052a029	journal	February 1993
Liquid Chromatography/Time-of-Flight Mass Spectrometry with a Pulsed Sample Introduction Interface Wang, Alan P. L.; Guo, Xijian.; Li, Liang. Analytical Chemistry, Vol. 66, Issue 21 https://doi.org/10.1021/ac00093a021	journal	November 1994
Liquid sample introduction for matrix-assisted laser desorption ionization Murray, Kermit K.; Russell, David H. Analytical Chemistry, Vol. 65, Issue 18 https://doi.org/10.1021/ac00066a023	journal	September 1993
A continuous-flow sample probe for fast atom bombardment mass spectrometry Caprioli, Richard M.; Fan, Terry.; Cottrell, John S. Analytical Chemistry, Vol. 58, Issue 14 https://doi.org/10.1021/ac00127a012	journal	December 1986
Atmospheric pressure ionization mass spectrometry. Detection for the separation sciences. Huang, Eric C.; Wachs, Timothy; Conboy, James J. Analytical Chemistry, Vol. 62, Issue 13 https://doi.org/10.1021/ac00212a002	journal	July 1990
Coupling capillary zone electrophoresis and continuous- flow fast atom bombardment mass spectrometry for the analysis of peptide mixtures Caprioli, Richard M.; Moore, William T.; Martin, Millie Journal of Chromatography A, Vol. 480 https://doi.org/10.1016/S0021-9673(01)84292-8	journal	January 1989
Capillary Electrophoresis Ewing, Andrew G.; Wallingford, Ross A.; Olefirowicz, Teresa M. Analytical Chemistry, Vol. 61, Issue 4 https://doi.org/10.1021/ac00179a722	journal	February 1989
Capillary electrophoresis Kuhr, Werner G.; Monnig, Curtis A. Analytical Chemistry, Vol. 64, Issue 12 https://doi.org/10.1021/ac00036a021	journal	June 1992
On-line mass spectrometric detection for capillary zone electrophoresis Olivares, Jose A.; Nguyen, Nhung T.; Yonker, Clement R. Analytical Chemistry, Vol. 59, Issue 8 https://doi.org/10.1021/ac00135a034	journal	April 1987
Mechanism of electrospray mass spectrometry. Electrospray as an electrolysis cell Blades, Arthur T.; Ikonomou, Michael G.; Kebarle, Paul. Analytical Chemistry, Vol. 63, Issue 19 https://doi.org/10.1021/ac00019a009	journal	October 1991
On-line capillary electrophoresis with Fourier transform ion cyclotron resonance mass spectrometry Hofstadler, Steven A.; Wahl, Jon H.; Bruce, James E. Journal of the American Chemical Society, Vol. 115, Issue 15 https://doi.org/10.1021/ja00068a070	journal	July 1993
Capillary zone electrophoresis-mass spectrometry using a coaxial continuous-flow fast atom bombardment interface Moseley, M. A.; Deterding, L. J.; Tomer, K. B. Journal of Chromatography A, Vol. 516, Issue 1 https://doi.org/10.1016/S0021-9673(01)90214-6	journal	September 1990
Electrospray ion source. Another variation on the free-jet theme Yamashita, Masamichi; Fenn, John B. The Journal of Physical Chemistry, Vol. 88, Issue 20 https://doi.org/10.1021/j150664a002	journal	September 1984
Capillary electrophoresis Kuhr, Werner G. Analytical Chemistry, Vol. 62, Issue 12 https://doi.org/10.1021/ac00211a027	journal	June 1990
Performance of a liquid-junction interface for capillary electrophoresis mass spectrometry using continuous-flow fast-atom bombardment Reinhoud, N. J.; Niessen, W. M. A.; Tjaden, U. R. Rapid Communications in Mass Spectrometry, Vol. 3, Issue 10 https://doi.org/10.1002/rcm.1290031009	journal	October 1989
Capillary zone electrophoresis: its applicability and potential in biochemical analysis Deyl, Z.; Struzinsky, R. Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 569, Issue 1-2 https://doi.org/10.1016/0378-4347(91)80227-4	journal	September 1991
Online Time-of-Flight Mass Spectrometric Analysis of Peptides Separated by Capillary Electrophoresis Fang, Liling.; Zhang, Rong.; Williams, Evan R. Analytical Chemistry, Vol. 66, Issue 21 https://doi.org/10.1021/ac00093a025	journal	November 1994
Quantitative Capillary Electrophoresis-Ion Spray Mass Spectrometry on a Benchtop Ion Trap for the Determination of Isoquinoline Alkaloids Henion, Jack D.; Mordehai, Alex V.; Cai, Jianyi. Analytical Chemistry, Vol. 66, Issue 13 https://doi.org/10.1021/ac00085a028	journal	July 1994
Liquid chromatography-time-of-flight mass spectrometry with continuous-flow matrix-assisted laser desorption ionization Nagra, Davinder S.; Li, Liang Journal of Chromatography A, Vol. 711, Issue 2 https://doi.org/10.1016/0021-9673(95)00658-A	journal	September 1995

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/250/
absorbing component
addition
analytes
buffer
component
coupling
coupling microscale
directly
directly coupling
facilitated
interface
ionization
ionization interface
laser
laser vaporization
laser-induced
light-absorbing
mass
mass spectrometer
mass spectrometry
microscale
microscale separation
processes
provides
scale separation
separated
separation
separation process
separation processes
separation technique
separation techniques
solvent
spectrometer
spectrometry
techniques
vaporization

Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry

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