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Title: Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry

Abstract

The present invention provides a laser-induced vaporization and ionization interface for directly coupling microscale separation processes to a mass spectrometer. Vaporization and ionization of the separated analytes are facilitated by the addition of a light-absorbing component to the separation buffer or solvent.

Inventors:
 [1];  [2]
  1. Ames, IA
  2. Taichung Hsien, TW
Publication Date:
Research Org.:
Ames Laboratory (AMES), Ames, IA; Iowa State Univ., Ames, IA (United States)
OSTI Identifier:
872359
Patent Number(s):
US 5917185
Application Number:
08/882,855
Assignee:
Iowa State University Research Foundation, Inc. (Ames, IA)
DOE Contract Number:  
W-7405-ENG-82
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
laser; vaporization; ionization; interface; coupling; microscale; separation; techniques; mass; spectrometry; provides; laser-induced; directly; processes; spectrometer; separated; analytes; facilitated; addition; light-absorbing; component; buffer; solvent; separation processes; separation techniques; separation process; mass spectrometer; mass spectrometry; absorbing component; microscale separation; ionization interface; separation technique; scale separation; directly coupling; laser vaporization; coupling microscale; /250/

Citation Formats

Yeung, Edward S, and Chang, Yu-chen. Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry. United States: N. p., 1999. Web.
Yeung, Edward S, & Chang, Yu-chen. Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry. United States.
Yeung, Edward S, and Chang, Yu-chen. 1999. "Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry". United States. https://www.osti.gov/servlets/purl/872359.
@article{osti_872359,
title = {Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry},
author = {Yeung, Edward S and Chang, Yu-chen},
abstractNote = {The present invention provides a laser-induced vaporization and ionization interface for directly coupling microscale separation processes to a mass spectrometer. Vaporization and ionization of the separated analytes are facilitated by the addition of a light-absorbing component to the separation buffer or solvent.},
doi = {},
url = {https://www.osti.gov/biblio/872359}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}

Works referenced in this record:

Continuous-flow matrix-assisted laser desorption ionization mass spectrometry
journal, February 1993


Mechanism of electrospray mass spectrometry. Electrospray as an electrolysis cell
journal, October 1991


Aerosol MALDI with a Reflectron Time-of-Flight Mass Spectrometer
journal, January 1996


Capillary zone electrophoresis-mass spectrometry using a coaxial continuous-flow fast atom bombardment interface
journal, September 1990


On-line mass spectrometric detection for capillary zone electrophoresis
journal, April 1987


Performance of a liquid-junction interface for capillary electrophoresis mass spectrometry using continuous-flow fast-atom bombardment
journal, October 1989


Electrospray ion source. Another variation on the free-jet theme
journal, September 1984


Capillary zone electrophoresis: its applicability and potential in biochemical analysis
journal, September 1991


On-line capillary electrophoresis with Fourier transform ion cyclotron resonance mass spectrometry
journal, July 1993


Liquid sample introduction for matrix-assisted laser desorption ionization
journal, September 1993


Capillary electrophoresis
journal, June 1992


Liquid Chromatography/Time-of-Flight Mass Spectrometry with a Pulsed Sample Introduction Interface
journal, November 1994


Capillary Electrophoresis
journal, February 1989


Online Time-of-Flight Mass Spectrometric Analysis of Peptides Separated by Capillary Electrophoresis
journal, November 1994


Atmospheric pressure ionization mass spectrometry. Detection for the separation sciences.
journal, July 1990


Capillary electrophoresis
journal, June 1990


Capillary electrophoresis
journal, November 1990


A continuous-flow sample probe for fast atom bombardment mass spectrometry
journal, December 1986