Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids

Miller, Paul S; Ts'o, Paul O.P.

Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids

Patent · Tue Jun 15 00:00:00 EDT 1999

OSTI ID:872330

Miller, Paul S ^[1]; Ts'o, Paul O.P. ^[2]

Baltimore, MD
Lutherville, MD

A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid and includes a functional group which reacts with the target nucleic acid to render the target nucleic acid inactive or nonfunctional.

Research Organization:: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-88ER60636

Assignee:: Johns Hopkins University (Baltimore, MD)

Patent Number(s):: US 5912339

Application Number:: 08/342005

OSTI ID:: 872330

Country of Publication:: United States

Language:: English

References (12)

Nonenzymatic sequence-specific cleavage of single-stranded DNA. Chu, B. C.; Orgel, L. E. Proceedings of the National Academy of Sciences, Vol. 82, Issue 4 https://doi.org/10.1073/pnas.82.4.963	journal	February 1985
Molecular Biology: Antisense Has Growing Pains Gura, T. Science, Vol. 270, Issue 5236 https://doi.org/10.1126/science.270.5236.575	journal	October 1995
Chemical synthesis of natural and modified oligodeoxynucleotides Thuong, N.; Asseline, U. Biochimie, Vol. 67, Issue 7-8 https://doi.org/10.1016/S0300-9084(85)80155-3	journal	July 1985
Effects of pendant groups at phosphorus on binding properties of d-ApA analogues Letsinger, R. L.; Bach, S. A.; Eadie, J. S. Nucleic Acids Research, Vol. 14, Issue 8 https://doi.org/10.1093/nar/14.8.3487	journal	January 1986
CpG motifs in bacterial DNA trigger direct B-cell activation Krieg, Arthur M.; Yi, Ae-Kyung; Matson, Sara Nature, Vol. 374, Issue 6522 https://doi.org/10.1038/374546a0	journal	April 1995
Hybridization triggered cross-linking of deoxyoligonucleotides Webb, Thomas R.; Matteucci, Mark D. Nucleic Acids Research, Vol. 14, Issue 19 https://doi.org/10.1093/nar/14.19.7661	journal	January 1986
Antiviral effect of oligo(nucleoside methylphosphonates) complementary to the herpes simplex virus type 1 immediate early mRNAs 4 and 5 Kulka, Michael; Wachsman, Matthew; Miura, Shunsuke Antiviral Research, Vol. 20, Issue 2 https://doi.org/10.1016/0166-3542(93)90002-Z	journal	February 1993
Oligonucleotide Analogues as Potential Chemotherapeutic Agents Zon, Gerald Pharmaceutical Research, Vol. 05, Issue 9, p. 539-549 https://doi.org/10.1023/A:1015985728434	journal	January 1988
Sequence-specific cleavage of single-stranded DNA: oligodeoxynucleotide-EDTA X Fe(II). Dreyer, G. B.; Dervan, P. B. Proceedings of the National Academy of Sciences, Vol. 82, Issue 4 https://doi.org/10.1073/pnas.82.4.968	journal	February 1985
Interaction of psoralen-derivatized oligodeoxyribonucleoside methylphosphonates with single-stranded DNA Lee, Bok L.; Murakami, Akira; Blake, Kathleen R. Biochemistry, Vol. 27, Issue 9 https://doi.org/10.1021/bi00409a011	journal	May 1988
Oligodeoxynucleotides covalently linked to intercalating agents: a new class of gene regulatory substances Helene, C.; Montenaygarestier, T.; Saison, T. Biochimie, Vol. 67, Issue 7-8 https://doi.org/10.1016/S0300-9084(85)80167-X	journal	July 1985
Synthesis of porphyrin(Fe)-intercalators which cause DNA scission Hashimoto, Yuichi; Lee, Ching-Shing; Shudo, Koichi Tetrahedron Letters, Vol. 24, Issue 14 https://doi.org/10.1016/S0040-4039(00)81699-8	journal	January 1983

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Related Subjects

/999/435/
acid
acids
alkyl
analogue
arylphosphonate
capable
cleaving
complementary
composition
comprises
crosslinking
derivatives
functional
inactivating
inactive
nonfunctional
nucleic
nucleic acid
nucleic acids
oligonucleoside
oligonucleoside alkyl
reacts
render
sequence
target
target nuclei
target nucleic

Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids

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References (12)

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