Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids
Patent
·
OSTI ID:6281399
A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid is provided. It includes a functional group which reacts with the target nucleic acid to render the target nucleic acid inactive or nonfunctional. 16 figs.
- Research Organization:
- The Johns Hopkins University (Baltimore, MD)
- Sponsoring Organization:
- DOE; NIH; USDOE, Washington, DC (United States); National Insts. of Health, Bethesda, MD (United States)
- DOE Contract Number:
- FG02-88ER60636
- Assignee:
- The Johns Hopkins University (Baltimore, MD)
- Patent Number(s):
- A; US 5912339
- Application Number:
- PPN: US 8-342005
- OSTI ID:
- 6281399
- Country of Publication:
- United States
- Language:
- English
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