Reduction of diffusional defocusing in hydrodynamically focused flows

Patent · Wed Dec 31 23:00:00 EST 1997

OSTI ID:871807

Affleck, Rhett L ^[1]; Demas, James N ^[2]; Goodwin, Peter M ^[3]; Keller, Richard ^[4]; Wu, Ming ^[5]

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1. Lawrenceville, NJ
2. Charlottesville, VA
3. Jemez Springs, NM
4. Los Alamos, NM
5. Middle Island, NY

An analyte fluid stream with first molecules having relatively low molecular weight and a corresponding high coefficient of diffusion has reduced diffusional defocusing out of an analyte fluid stream. The analyte fluid stream of first molecules is associated with second molecules of relatively high molecular weight having a relatively low coefficient of diffusion and a binding constant effective to associate with the first molecules. A focused analyte fluid stream is maintained since the combined molecular weight of the associated first and second molecules is effective to minimize diffusion of the first molecules out of the analyte fluid stream.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM
• DOE Contract Number: W-7405-ENG-36
• Assignee: Regents of University of California (Los Alamos, NM)
• Patent Number(s): US 5799682
• OSTI ID: 871807
• Country of Publication: United States
• Language: English

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diffusion
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effective
flows
fluid
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focused
hydrodynamically
maintained
minimize
molecular
molecular weight
molecules
reduced
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relatively
stream
weight