Reduction of diffusional defocusing in hydrodynamically focused flows

Patent · Tue Sep 01 00:00:00 EDT 1998

OSTI ID:672656

Affleck, R L; Demas, J N; Goodwin, P M; Keller, R; Wu, M

An analyte fluid stream with first molecules having relatively low molecular weight and a corresponding high coefficient of diffusion has reduced diffusional defocusing out of an analyte fluid stream. The analyte fluid stream of first molecules is associated with second molecules of relatively high molecular weight having a relatively low coefficient of diffusion and a binding constant effective to associate with the first molecules. A focused analyte fluid stream is maintained since the combined molecular weight of the associated first and second molecules is effective to minimize diffusion of the first molecules out of the analyte fluid stream. 6 figs.

• Research Organization: University of California
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: W-7405-ENG-36
• Assignee: Univ. of California, Los Alamos, NM (United States)
• Patent Number(s): US 5,799,682/A/
• Application Number: PAN: 8-758,738
• OSTI ID: 672656
• Country of Publication: United States
• Language: English

Related Subjects

40 CHEMISTRY
ADSORPTION
CHEMICAL ANALYSIS
DIFFUSION
FLUID FLOW
LIQUIDS
MITIGATION
MOLECULAR WEIGHT
SAMPLE PREPARATION