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Title: Biomarkers of cell senescence

Patent ·
OSTI ID:871786
 [1];  [2];  [3]
  1. Simli U.P., IN
  2. Berkeley, CA
  3. Newton, MA
+ Show Author Affiliations

The present invention provides a biomarker system for the in vivo and in vitro assessment of cell senescence. In the method of the present invention, .beta.-galactosidase activity is utilized as a means by which cell senescence may be assessed either in vitro cell cultures or in vivo.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
DOE Contract Number:
AC03-76SF00098
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 5795728
OSTI ID:
871786
Country of Publication:
United States
Language:
English

References (15)

Molecular genetic approaches to the study of cellular senescence journal March 1991
Age-related cell surface changes in human diploid fibroblasts revealed by lectin-mediated red blood cell adsorption assay: A lectin survey journal November 1979
Cell sorting and microchemistry of cultured human fibroblasts: Applications in genetics and aging research journal March 1984
The limited in vitro lifetime of human diploid cell strains journal March 1965
Loss of a critical neutral protease in ageing WI-38 cells journal June 1976
Cellular senescence: A reflection of normal growth control, differentiation, or aging? journal February 1991
The serial cultivation of human diploid cell strains journal December 1961
Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on human chromosome 4. journal July 1991
Suppression of tumor growth by senescence in virally transformed human fibroblasts. journal November 1986
Senescence-induced alteration in cell surface carbohydrates correlated using proton NMR spectroscopy and a lectin-based affinity-binding assay journal September 1989
Replicative senescence: the human fibroblast comes of age journal September 1990
Immortal phenotype of the HeLa variant D98 is recessive in hybrids formed with normal human fibroblasts journal May 1990
β-Galactosidase Activity in Transfected Ltk- Cells is Differentially Regulated in Monolayer and in Spheroid Cultures journal July 1993
Tumor suppression by chromosome 11 is not due to cellular senescence journal January 1991
Cellular aging and senescence journal April 1991

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Related Subjects

biomarkers
cell
senescence
provides
biomarker
vivo
vitro
assessment
method
beta
-galactosidase
activity
utilized
means
assessed
cultures
cell senescence
cell culture
cell cultures
vitro assessment
vitro cell
-galactosidase activity
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