Biomarkers of cell senescence

Dimri, Goberdhan P; Campisi, Judith; Peacocke, Monica

Biomarkers of cell senescence

Patent · Wed Dec 31 23:00:00 EST 1997

OSTI ID:871786

Dimri, Goberdhan P ^[1]; Campisi, Judith ^[2]; Peacocke, Monica ^[3]

Simli U.P., IN
Berkeley, CA
Newton, MA

The present invention provides a biomarker system for the in vivo and in vitro assessment of cell senescence. In the method of the present invention, .beta.-galactosidase activity is utilized as a means by which cell senescence may be assessed either in vitro cell cultures or in vivo.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA

DOE Contract Number:: AC03-76SF00098

Assignee:: Regents of University of California (Oakland, CA)

Patent Number(s):: US 5795728

OSTI ID:: 871786

Country of Publication:: United States

Language:: English

References (15)

Cellular aging and senescence McCormick, Anna; Campisi, Judith Current Opinion in Cell Biology, Vol. 3, Issue 2 https://doi.org/10.1016/0955-0674(91)90144-N	journal	April 1991
Suppression of tumor growth by senescence in virally transformed human fibroblasts. O'Brien, W.; Stenman, G.; Sager, R. Proceedings of the National Academy of Sciences, Vol. 83, Issue 22 https://doi.org/10.1073/pnas.83.22.8659	journal	November 1986
The limited in vitro lifetime of human diploid cell strains Hayflick, L. Experimental Cell Research, Vol. 37, Issue 3 https://doi.org/10.1016/0014-4827(65)90211-9	journal	March 1965
Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on human chromosome 4. Ning, Y.; Weber, J. L.; Killary, A. M. Proceedings of the National Academy of Sciences, Vol. 88, Issue 13 https://doi.org/10.1073/pnas.88.13.5635	journal	July 1991
Replicative senescence: the human fibroblast comes of age Goldstein, S. Science, Vol. 249, Issue 4973 https://doi.org/10.1126/science.2204114	journal	September 1990
Age-related cell surface changes in human diploid fibroblasts revealed by lectin-mediated red blood cell adsorption assay: A lectin survey Aizawa, Shinichi; Kurimoto, Fumiko Mechanisms of Ageing and Development, Vol. 11, Issue 4 https://doi.org/10.1016/0047-6374(79)90004-6	journal	November 1979
Molecular genetic approaches to the study of cellular senescence Ning, Yi; Pereira-Smith, Olivia M. Mutation Research/DNAging, Vol. 256, Issue 2-6 https://doi.org/10.1016/0921-8734(91)90021-3	journal	March 1991
Senescence-induced alteration in cell surface carbohydrates correlated using proton NMR spectroscopy and a lectin-based affinity-binding assay Busse, Scott C.; Mann, Paul L.; Griffey, Richard H. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 984, Issue 2 https://doi.org/10.1016/0005-2736(89)90214-9	journal	September 1989
The serial cultivation of human diploid cell strains Hayflick, L.; Moorhead, P. S. Experimental Cell Research, Vol. 25, Issue 3 https://doi.org/10.1016/0014-4827(61)90192-6	journal	December 1961
Tumor suppression by chromosome 11 is not due to cellular senescence Ning, Yi; Shay, Jerry W.; Lovell, Mercedes Experimental Cell Research, Vol. 192, Issue 1 https://doi.org/10.1016/0014-4827(91)90179-X	journal	January 1991
Cellular senescence: A reflection of normal growth control, differentiation, or aging? Peacocke, Monica; Campisi, Judith Journal of Cellular Biochemistry, Vol. 45, Issue 2 https://doi.org/10.1002/jcb.240450205	journal	February 1991
Immortal phenotype of the HeLa variant D98 is recessive in hybrids formed with normal human fibroblasts Pereira-Smith, Olivia M.; Stein, Gretchen H.; Robetorye, Susan Journal of Cellular Physiology, Vol. 143, Issue 2 https://doi.org/10.1002/jcp.1041430204	journal	May 1990
β-Galactosidase Activity in Transfected Ltk- Cells is Differentially Regulated in Monolayer and in Spheroid Cultures Klünder, Irene; Hülser, Dieter F. Experimental Cell Research, Vol. 207, Issue 1 https://doi.org/10.1006/excr.1993.1175	journal	July 1993
Loss of a critical neutral protease in ageing WI-38 cells Bosmann, H. Bruce; Gutheil, Roger L.; Case, Kenneth R. Nature, Vol. 261, Issue 5560 https://doi.org/10.1038/261499a0	journal	June 1976
Cell sorting and microchemistry of cultured human fibroblasts: Applications in genetics and aging research Jongkind, Johan F.; Verkerk, Anton Cytometry, Vol. 5, Issue 2 https://doi.org/10.1002/cyto.990050212	journal	March 1984

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Biomarkers of cell senescence

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References (15)

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