Biomarkers of cell senescence

Dirmi, Goberdhan P; Campisi, Judith; Peacocke, Monica

Biomarkers of cell senescence

Patent · Sun Dec 31 23:00:00 EST 1995

OSTI ID:870293

Dirmi, Goberdhan P ^[1]; Campisi, Judith ^[2]; Peacocke, Monica ^[3]

Simli U.P., IN
Berkeley, CA
Newton, MA

The present invention provides a biomarker system for the in vivo and in vitro assessment of cell senescence. In the method of the present invention, .beta.-galactosidase activity is utilized as a means by which cell senescence may be assessed either in in vitro cell cultures or in vivo.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA

DOE Contract Number:: AC03-76SF00098

Assignee:: Regents of University of California (Oakland, CA)

Patent Number(s):: US 5491069

OSTI ID:: 870293

Country of Publication:: United States

Language:: English

References (29)

Cellular aging and senescence McCormick, Anna; Campisi, Judith Current Opinion in Cell Biology, Vol. 3, Issue 2 https://doi.org/10.1016/0955-0674(91)90144-N	journal	April 1991
Induction of cellular senescence in immortalized cells by human chromosome 1 Sugawara, O.; Oshimura, M.; Koi, M. Science, Vol. 247, Issue 4943 https://doi.org/10.1126/science.2300822	journal	February 1990
Suppression of tumor growth by senescence in virally transformed human fibroblasts. O'Brien, W.; Stenman, G.; Sager, R. Proceedings of the National Academy of Sciences, Vol. 83, Issue 22 https://doi.org/10.1073/pnas.83.22.8659	journal	November 1986
The limited in vitro lifetime of human diploid cell strains Hayflick, L. Experimental Cell Research, Vol. 37, Issue 3 https://doi.org/10.1016/0014-4827(65)90211-9	journal	March 1965
Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on human chromosome 4. Ning, Y.; Weber, J. L.; Killary, A. M. Proceedings of the National Academy of Sciences, Vol. 88, Issue 13 https://doi.org/10.1073/pnas.88.13.5635	journal	July 1991
Further studies on the genetic and biochemical basis of cellular senescence Smith, James R.; Pereira-Smith, Olivia M. Experimental Gerontology, Vol. 24, Issue 5-6 https://doi.org/10.1016/0531-5565(89)90045-4	journal	January 1989
Replicative senescence: the human fibroblast comes of age Goldstein, S. Science, Vol. 249, Issue 4973 https://doi.org/10.1126/science.2204114	journal	September 1990
Age-related cell surface changes in human diploid fibroblasts revealed by lectin-mediated red blood cell adsorption assay: A lectin survey Aizawa, Shinichi; Kurimoto, Fumiko Mechanisms of Ageing and Development, Vol. 11, Issue 4 https://doi.org/10.1016/0047-6374(79)90004-6	journal	November 1979
Evidence for the Recessive Nature of Cellular Immortality Pereira-Smith, O. M.; Smith, J. R. Science, Vol. 221, Issue 4614, p. 964-966 https://doi.org/10.1126/science.6879195	journal	September 1983
Cellular Senescence revisited: a review Stanulis-Praeger, BetzabéM. Mechanisms of Ageing and Development, Vol. 38, Issue 1 https://doi.org/10.1016/0047-6374(87)90109-6	journal	March 1987
Molecular genetic approaches to the study of cellular senescence Ning, Yi; Pereira-Smith, Olivia M. Mutation Research/DNAging, Vol. 256, Issue 2-6 https://doi.org/10.1016/0921-8734(91)90021-3	journal	March 1991
Altered gene expression during cellular aging Smith, James R.; Pereira-Smith, Olivia M. Genome, Vol. 31, Issue 1 https://doi.org/10.1139/g89-058	journal	January 1989
Novel monoclonal antibodies identify antigenic determinants unique to cellular senescence Porter, Mary Beth; Pereira-Smith, Olivia M.; Smith, James R. Journal of Cellular Physiology, Vol. 142, Issue 2 https://doi.org/10.1002/jcp.1041420228	journal	February 1990
Senescence-induced alteration in cell surface carbohydrates correlated using proton NMR spectroscopy and a lectin-based affinity-binding assay Busse, Scott C.; Mann, Paul L.; Griffey, Richard H. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 984, Issue 2 https://doi.org/10.1016/0005-2736(89)90214-9	journal	September 1989
Correlation between complementation group for immortality and DNA synthesis inhibitors*1 Spiering, A. Experimental Cell Research, Vol. 195, Issue 2 https://doi.org/10.1016/0014-4827(91)90409-N	journal	August 1991
Genetic analysis of indefinite division in human cells: identification of four complementation groups. Pereira-Smith, O. M.; Smith, J. R. Proceedings of the National Academy of Sciences, Vol. 85, Issue 16 https://doi.org/10.1073/pnas.85.16.6042	journal	August 1988
The serial cultivation of human diploid cell strains Hayflick, L.; Moorhead, P. S. Experimental Cell Research, Vol. 25, Issue 3 https://doi.org/10.1016/0014-4827(61)90192-6	journal	December 1961
Tumor suppression by chromosome 11 is not due to cellular senescence Ning, Yi; Shay, Jerry W.; Lovell, Mercedes Experimental Cell Research, Vol. 192, Issue 1 https://doi.org/10.1016/0014-4827(91)90179-X	journal	January 1991
Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts Wright, W. E.; Pereira-Smith, O. M.; Shay, J. W. Molecular and Cellular Biology, Vol. 9, Issue 7 https://doi.org/10.1128/mcb.9.7.3088-3092.1989	journal	July 1989
Cellular senescence: A reflection of normal growth control, differentiation, or aging? Peacocke, Monica; Campisi, Judith Journal of Cellular Biochemistry, Vol. 45, Issue 2 https://doi.org/10.1002/jcb.240450205	journal	February 1991
Immortal phenotype of the HeLa variant D98 is recessive in hybrids formed with normal human fibroblasts Pereira-Smith, Olivia M.; Stein, Gretchen H.; Robetorye, Susan Journal of Cellular Physiology, Vol. 143, Issue 2 https://doi.org/10.1002/jcp.1041430204	journal	May 1990
β-Galactosidase Activity in Transfected Ltk- Cells is Differentially Regulated in Monolayer and in Spheroid Cultures Klünder, Irene; Hülser, Dieter F. Experimental Cell Research, Vol. 207, Issue 1 https://doi.org/10.1006/excr.1993.1175	journal	July 1993
Expression of c-fos and AP-1 activity in senescent human fibroblasts is not sufficient for DNA synthesis. Rose, D. W.; McCabe, G.; Feramisco, J. R. Journal of Cell Biology, Vol. 119, Issue 6 https://doi.org/10.1083/jcb.119.6.1405	journal	December 1992
Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts Seshadri, T.; Campisi, J. Science, Vol. 247, Issue 4939 https://doi.org/10.1126/science.2104680	journal	January 1990
Loss of a critical neutral protease in ageing WI-38 cells Bosmann, H. Bruce; Gutheil, Roger L.; Case, Kenneth R. Nature, Vol. 261, Issue 5560 https://doi.org/10.1038/261499a0	journal	June 1976
Dissociation of senescence-associated changes in differentiated gene expression and replicative senescence in cultured adrenocortical cells Yang, L. Q.; Hornsby, P. J. Journal of Cell Science, Vol. 94, Issue 4 https://doi.org/10.1242/jcs.94.4.757	journal	December 1989
Genetic and Molecular Studies of Cellular Immortalization Smith, James R.; Pereira-Smith, Olivia M. Advances in Cancer Research https://doi.org/10.1016/S0065-230X(08)60808-8	book	January 1990
Cell sorting and microchemistry of cultured human fibroblasts: Applications in genetics and aging research Jongkind, Johan F.; Verkerk, Anton Cytometry, Vol. 5, Issue 2 https://doi.org/10.1002/cyto.990050212	journal	March 1984
Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity West, Michael D.; Pereira-Smith, Olivia M.; Smith, James R. Experimental Cell Research, Vol. 184, Issue 1 https://doi.org/10.1016/0014-4827(89)90372-8	journal	September 1989

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Biomarkers of cell senescence

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