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Apparatus and method of determining molecular weight of large molecules

Patent ·
OSTI ID:871650
 [1];  [2];  [3];  [4]
  1. Montrose, CA
  2. Danville, CA
  3. Livermore, CA
  4. Fremont, CA
+ Show Author Affiliations

A mass spectrometer determines the mass of multiply charged high molecular weight molecules. This spectrometer utilizes an ion detector which is capable of simultaneously measuring the charge z and transit time of a single ion as it passes through the detector. From this transit time, the velocity of the single ion may then be derived, thus providing the mass-to-charge ratio m/z for a single ion which has been accelerated through a known potential. Given z and m/z, the mass m of the single ion can then be calculated. Electrospray ions with masses in excess of 1 MDa and charge numbers greater than 425 e.sup.- are readily detected. The on-axis single ion detection configuration enables a duty cycle of nearly 100% and extends the practical application of electrospray mass spectrometry to the analysis of very large molecules with relatively inexpensive instrumentation.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
DOE Contract Number:
AC03-76SF00098
Assignee:
Regents, University of California (Oakland, CA)
Patent Number(s):
US 5770857
OSTI ID:
871650
Country of Publication:
United States
Language:
English

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100
425
accelerated
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apparatus
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capable
charge
charged
configuration
cycle
derived
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detection
detector
determines
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determining molecular
duty
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electrospray
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excess
extends
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mass
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multiply
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z