Bismuth generator method

Patent · Wed Dec 31 23:00:00 EST 1997

OSTI ID:871534

Bray, Lane Allan ^[1]; DesChane, Jaquetta R ^[2]

---

1. Richland, WA
2. Pasco, WA

A method for separating .sup.213 Bi from a solution of radionuclides wherein the solution contains a concentration of the chloride ions and hydrogen ions adjusted to allow the formation of a chloride complex. The solution is then brought into contact with an anion exchange resin, whereupon .sup.213 Bi is absorbed from the solution and adhered onto the anion exchange resin in the chloride complex. Other non-absorbing radionuclides such as .sup.225 Ra, .sup.225 Ac, and .sup.221 Fr, along with HCl are removed from the anion exchange resin with a scrub solution. The .sup.213 Bi is removed from the anion exchange resin by washing the anion exchange resin with a stripping solution free of chloride ions and with a reduced hydrogen ion concentration which breaks the chloride anionic complex, releasing the .sup.213 Bi as a cation. In a preferred embodiment of the present invention, the anion exchange resin is provided as a thin membrane, allowing for extremely rapid adherence and stripping of the .sup.213 Bi. A preferred stripping solution for purification of .sup.213 Bi for use in medical applications includes sodium acetate, pH 5.5. A protein conjugated with bifunctional chelating agents in vivo with the NaOAc, to receive the .sup.213 Bi as it is being released from the anion exchange resin.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA
• DOE Contract Number: AC06-76RL01830
• Assignee: Battelle Memorial Institute (Richland, WA)
• Patent Number(s): US 5749042
• OSTI ID: 871534
• Country of Publication: United States
• Language: English

Related Subjects

/423/210/376/
213
221
225
absorbed
acetate
adhered
adherence
adjusted
agents
allow
allowing
anion
anion exchange
anionic
anionic complex
applications
bifunctional
bifunctional chelating
bismuth
breaks
brought
cation
chelating
chelating agent
chelating agents
chloride
chloride complex
complex
concentration
conjugated
contact
contains
embodiment
exchange
exchange resin
extremely
extremely rapid
formation
free
generator
hcl
hydrogen
medical
medical applications
membrane
method
naoac
non-absorbing
ph
preferred
preferred embodiment
protein
provided
purification
radionuclides
rapid
receive
reduced
released
releasing
removed
resin
scrub
scrub solution
separating
sodium
sodium acetate
solution
solution contains
stripping
stripping solution
vivo
washing
whereupon