An electrochemical generator for the continual supply of 213Bi from 225Ac for use in targeted alpha therapy applications

Forrester, Ryan; Dutech, Guy; Akin, Andrew; Fassbender, Michael E.; Mastren, Tara

doi:10.1016/j.nucmedbio.2024.108941

An electrochemical generator for the continual supply of ²¹³Bi from ²²⁵Ac for use in targeted alpha therapy applications

Journal Article · Tue Jul 09 00:00:00 EDT 2024 · Nuclear Medicine and Biology

DOI:https://doi.org/10.1016/j.nucmedbio.2024.108941· OSTI ID:2433936

Forrester, Ryan ^[1]; ^[2]; ^[2]; ^[2]; Mastren, Tara ^[1]

Univ. of Utah, Salt Lake City, UT (United States)
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Bismuth-213 is a radionuclide of interest for targeted alpha therapy and is supplied via a radiochemical generator system through the decay of ²²⁵Ac. Radionuclide generators employ longer lived “parent” radionuclides to routinely supply shorter-lived “daughter” radionuclides. The traditional ²²⁵Ac/²¹³Bi radiochemical generator relies on an organic cation exchange resin where ²²⁵Ac binds to the resin and ²¹³Bi is routinely eluted. These resins degrade when they absorb large doses of ionizing radiation (>1 × 10⁶ Gy/mg), which has been observed when the loading activity of ²²⁵Ac exceeds 2.59*10⁹ Bq (70 mCi). Herein we report the development of an electrochemical generator for the supply of 213Bi that has the potential to overcome this limitation. Bismuth-213 spontaneously electrodeposits onto nickel foils in 0.1 M hydrochloric acid at 70 °C. Using this method, we were able to plate an average of 73 ± 4 % of the ²¹³Bi in solution and obtain a final ²¹³Bi recovery of 65 ± 8 % in 0.1 M citrate pH 4.5 via reverse electrolysis using titanium as the cathode. The recovered 213Bi had an average radiochemical purity of >99.8 % and was successfully used to radiolabel DOTATATE with an average radiochemical yield of 85.1 % (not optimized).

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE Laboratory Directed Research and Development (LDRD) Program

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 2433936

Report Number(s):: LA-UR--24-22113

Journal Information:: Nuclear Medicine and Biology, Journal Name: Nuclear Medicine and Biology Vol. 136-137; ISSN 0969-8051

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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An electrochemical generator for the continual supply of 213Bi from 225Ac for use in targeted alpha therapy applications

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References (18)

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An electrochemical generator for the continual supply of ²¹³Bi from ²²⁵Ac for use in targeted alpha therapy applications