Inorganic resins for clinical use of 213Bi generators

DePaoli, David W.; Hu, Michael Z.; Mirzadeh, Saed; Clavier, John W.

Inorganic resins for clinical use of ²¹³Bi generators

Patent · Tue Mar 29 00:00:00 EDT 2011

OSTI ID:1015585

DePaoli, David W. ^[1]; Hu, Michael Z. ^[1]; Mirzadeh, Saed ^[1]; Clavier, John W. ^[2]

Knoxville, TN
Elizabethton, TN

Applicant's invention is a radionuclide generator resin material for radiochemical separation of daughter radionuclides, particularly ²¹³Bi, from a solution of parental radionuclides, the resin material capable of providing clinical quantities of ²¹³Bi of at least 20-mCi, wherein the resin material comprises a silica-based structure having at least one bifunctional ligand covalently attached to the surface of the silica-based structure. The bifunctional ligand comprises a chemical group having desirable surface functionality to enable the covalent attachment of the bifunctional ligand thereon the surface of the structure and the bifunctional ligand further comprises a second chemical group capable of binding and holding the parental radionuclides on the resin material while allowing the daughter radionuclides to elute off the resin material. The bifunctional ligand has a carbon chain with a limited number of carbons to maintain radiation stability of the resin material.

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-00OR22725

Assignee:: UT-Battelle LLC (Oak Ridge, TN)

Patent Number(s):: 7,914,766

Application Number:: 10/860,520

OSTI ID:: 1015585

Country of Publication:: United States

Language:: English

References (12)

Radionuclides for Radioimmunotherapy: Criteria for Selection Geerlings, M. W. The International Journal of Biological Markers, Vol. 8, Issue 3 https://doi.org/10.1177/172460089300800308	journal	July 1993
Templating of Mesoporous Molecular Sieves by Nonionic Polyethylene Oxide Surfactants Bagshaw, S. A.; Prouzet, E.; Pinnavaia, T. J. Science, Vol. 269, Issue 5228 https://doi.org/10.1126/science.269.5228.1242	journal	September 1995
Development of a Unique Bismuth (Bi-213) Automated Generator for Use in Cancer Therapy Bray, Lane A.; Tingey, Joel M.; DesChane, Jaquetta R. Industrial & Engineering Chemistry Research, Vol. 39, Issue 9 https://doi.org/10.1021/ie990068r	journal	September 2000
A review of the radiation stability of ion exchange materials Pillay, K. K. S. Journal of Radioanalytical and Nuclear Chemistry Articles, Vol. 102, Issue 1 https://doi.org/10.1007/BF02037966	journal	November 1986
Recovery of Bi-213 from an Ac-225 Cow: Application to the Radiolabeling of Antibodies with Bi-213 Pippin, C. Greg; Gansow, Otto A.; Brechbiel, Martin W. Chemists’ Views of Imaging Centers https://doi.org/10.1007/978-1-4757-9670-4_35	book	January 1995
A new family of mesoporous molecular sieves prepared with liquid crystal templates Beck, J. S.; Vartuli, J. C.; Roth, W. J. Journal of the American Chemical Society, Vol. 114, Issue 27, p. 10834-10843 https://doi.org/10.1021/ja00053a020	journal	December 1992
The sol-gel process Hench, Larry L.; West, Jon K. Chemical Reviews, Vol. 90, Issue 1 https://doi.org/10.1021/cr00099a003	journal	January 1990
The feasibility of 225 Ac as a source of ??-particles in radioimmunotherapy Geerlings, M. W.; Kaspersen, F. M.; Apostolidis, C. Nuclear Medicine Communications, Vol. 14, Issue 2 https://doi.org/10.1097/00006231-199302000-00009	journal	January 1993
Double pore silica gel monolith applied to liquid chromatography Nakanishi, K.; Minakuchi, H.; Soga, N. Journal of Sol-Gel Science and Technology, Vol. 8, Issue 1-3 https://doi.org/10.1007/BF02436897	journal	February 1997
An Improved Generator for the Production of 213Bi from 225Ac Wu, Chuanchu; Brechbiel, Martin W.; Gansow, Otto A. Radiochimica Acta, Vol. 79, Issue 2 https://doi.org/10.1524/ract.1997.79.2.141	journal	January 1997
Optimizations of Radiolabeling of Immunoproteins with 213Bi Boll, Rose A.; Mirzadeh, Saed; Kennel, Stephen J. Radiochimica Acta, Vol. 79, Issue 2 https://doi.org/10.1524/ract.1997.79.2.145	journal	January 1997
The Sol-Gel Preparation of Silica Gels Buckley, A. M.; Greenblatt, M. Journal of Chemical Education, Vol. 71, Issue 7 https://doi.org/10.1021/ed071p599	journal	July 1994

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Inorganic resins for clinical use of 213Bi generators

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