Inorganic resins for clinical use of ²¹³Bi generators

Patent · Tue Mar 29 00:00:00 EDT 2011

OSTI ID:1015585

DePaoli, David W. ^[1]; Hu, Michael Z. ^[1]; Mirzadeh, Saed ^[1]; Clavier, John W. ^[2]

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1. Knoxville, TN
2. Elizabethton, TN

Applicant's invention is a radionuclide generator resin material for radiochemical separation of daughter radionuclides, particularly ²¹³Bi, from a solution of parental radionuclides, the resin material capable of providing clinical quantities of ²¹³Bi of at least 20-mCi, wherein the resin material comprises a silica-based structure having at least one bifunctional ligand covalently attached to the surface of the silica-based structure. The bifunctional ligand comprises a chemical group having desirable surface functionality to enable the covalent attachment of the bifunctional ligand thereon the surface of the structure and the bifunctional ligand further comprises a second chemical group capable of binding and holding the parental radionuclides on the resin material while allowing the daughter radionuclides to elute off the resin material. The bifunctional ligand has a carbon chain with a limited number of carbons to maintain radiation stability of the resin material.

• Research Organization: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-00OR22725
• Assignee: UT-Battelle LLC (Oak Ridge, TN)
• Patent Number(s): 7,914,766
• Application Number: 10/860,520
• OSTI ID: 1015585
• Resource Relation: Patent File Date: 2004 Jun 03
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE