Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Noise suppressing capillary separation system

Patent ·
OSTI ID:870536
 [1];  [2]
  1. Ames, IA
  2. Norwich, NY
+ Show Author Affiliations

A noise-suppressing capillary separation system for detecting the real-time presence or concentration of an analyte in a sample is provided. The system contains a capillary separation means through which the analyte is moved, a coherent light source that generates a beam which is split into a reference beam and a sample beam that irradiate the capillary, and a detector for detecting the reference beam and the sample beam light that transmits through the capillary. The laser beam is of a wavelength effective to be absorbed by a chromophore in the capillary. The system includes a noise suppressing system to improve performance and accuracy without signal averaging or multiple scans.

Research Organization:
Ames Laboratory (AMES), Ames, IA; Iowa State University, Ames, IA (US)
DOE Contract Number:
W-7405-ENG-82
Assignee:
Iowa State University Research Foundation, Inc. (Ames, IA)
Patent Number(s):
US 5540825
Application Number:
08/406,714
OSTI ID:
870536
Country of Publication:
United States
Language:
English

References (9)

Reaching the shot Noise Limit for $10 journal January 1991
Detection method for ion chromatography based on double-beam laser-excited indirect fluorometry journal October 1985
Capillary Electrophoresis journal February 1989
Double-beam laser absorption spectroscopy: shot noise-limited performance at baseband with a novel electronic noise canceler
  • Haller, Kurt L.; Hobbs, Philip C. D.
  • Optics, Electro-Optics, and Laser Applications in Science and Engineering, SPIE Proceedings https://doi.org/10.1117/12.44253
conference July 1991
Determination of amino acids by capillary zone electrophoresis based on semiconductor laser fluorescence detection journal April 1992
Diode laser-based indirect absorbance detector for capillary electrophoresis journal April 1993
Indirect Detection Methods for Capillary Separations journal March 1991
Axial-beam absorbance detection for capillary electrophoresis journal January 1991
Shot noise limited optical measurements at baseband with noisy lasers (proceedings Only) conference March 1991

Similar Records

Noise suppressing capillary separation system
Patent · Tue Jul 30 00:00:00 EDT 1996 · OSTI ID:264550
Suppressed conductometric capillary electrophoresis separation systems
Journal Article · Thu Apr 15 00:00:00 EDT 1993 · Analytical Chemistry (Washington); (United States) · OSTI ID:5848117
Integrated multiplexed capillary electrophoresis system
Patent · Mon Dec 31 23:00:00 EST 2001 · OSTI ID:874423

Related Subjects

/204/73/356/
absorbed
accuracy
analyte
averaging
beam
beam light
capillary
capillary separation
chromophore
coherent
coherent light
concentration
contains
detecting
detector
effective
generates
improve
improve performance
irradiate
laser
laser beam
light
light source
means
moved
multiple
noise
noise-suppressing
performance
presence
provided
real-time
reference
reference beam
sample
sample beam
scans
separation
separation means
signal
source
split
suppressing
suppressing capillary
transmits
wavelength
wavelength effective