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Title: Noise suppressing capillary separation system

Patent ·
OSTI ID:870536
 [1];  [2]
  1. Ames, IA
  2. Norwich, NY
+ Show Author Affiliations

A noise-suppressing capillary separation system for detecting the real-time presence or concentration of an analyte in a sample is provided. The system contains a capillary separation means through which the analyte is moved, a coherent light source that generates a beam which is split into a reference beam and a sample beam that irradiate the capillary, and a detector for detecting the reference beam and the sample beam light that transmits through the capillary. The laser beam is of a wavelength effective to be absorbed by a chromophore in the capillary. The system includes a noise suppressing system to improve performance and accuracy without signal averaging or multiple scans.

Research Organization:
Ames Laboratory (AMES), Ames, IA; Iowa State Univ., Ames, IA (United States)
DOE Contract Number:
W-7405-ENG-82
Assignee:
Iowa State University Research Foundation, Inc. (Ames, IA)
Patent Number(s):
US 5540825
Application Number:
08/406,714
OSTI ID:
870536
Country of Publication:
United States
Language:
English

References (9)

Reaching the shot Noise Limit for $10 journal January 1991
Capillary Electrophoresis journal February 1989
Indirect Detection Methods for Capillary Separations journal March 1991
Double-beam laser absorption spectroscopy: shot noise-limited performance at baseband with a novel electronic noise canceler
  • Haller, Kurt L.; Hobbs, Philip C. D.
  • Optics, Electro-Optics, and Laser Applications in Science and Engineering, SPIE Proceedings https://doi.org/10.1117/12.44253
conference July 1991
Detection method for ion chromatography based on double-beam laser-excited indirect fluorometry journal October 1985
Axial-beam absorbance detection for capillary electrophoresis journal January 1991
Determination of amino acids by capillary zone electrophoresis based on semiconductor laser fluorescence detection journal April 1992
Shot noise limited optical measurements at baseband with noisy lasers (proceedings Only) conference March 1991
Diode laser-based indirect absorbance detector for capillary electrophoresis journal April 1993

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Related Subjects

noise
suppressing
capillary
separation
noise-suppressing
detecting
real-time
presence
concentration
analyte
sample
provided
contains
means
moved
coherent
light
source
generates
beam
split
reference
irradiate
detector
transmits
laser
wavelength
effective
absorbed
chromophore
improve
performance
accuracy
signal
averaging
multiple
scans
reference beam
light source
laser beam
coherent light
sample beam
separation means
wavelength effective
beam light
capillary separation
improve performance
suppressing capillary
/204/73/356/