Methods and apparatus for analysis of chromatographic migration patterns
Patent
·
OSTI ID:869094
- Salt Lake City, UT
A method and apparatus for sharpening signal peaks in a signal representing the distribution of biological or chemical components of a mixture separated by a chromatographic technique such as, but not limited to, electrophoresis. A key step in the method is the use of a blind deconvolution technique, presently embodied as homomorphic filtering, to reduce the contribution of a blurring function to the signal encoding the peaks of the distribution. The invention further includes steps and apparatus directed to determination of a nucleotide sequence from a set of four such signals representing DNA sequence data derived by electrophoretic means.
- Research Organization:
- University of Utah
- DOE Contract Number:
- FG02-88ER60700
- Assignee:
- University of Utah Research Foundation (Salt Lake City, UT)
- Patent Number(s):
- US 5273632
- OSTI ID:
- 869094
- Country of Publication:
- United States
- Language:
- English
Blind deconvolution through digital signal processing
|
journal | January 1975 |
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Related Subjects
/204/210/436/702/
analysis
apparatus
biological
blind
blurring
chemical
chemical component
chemical components
chromatographic
components
contribution
data
data derived
deconvolution
derived
determination
directed
distribution
dna
dna sequence
electrophoresis
electrophoretic
embodied
encoding
filtering
function
homomorphic
key
limited
means
method
methods
migration
mixture
mixture separated
nucleotide
nucleotide sequence
patterns
peaks
presently
reduce
representing
separated
sequence
set
sharpening
signal
signal peak
signal representing
signals
signals representing
step
steps
technique
analysis
apparatus
biological
blind
blurring
chemical
chemical component
chemical components
chromatographic
components
contribution
data
data derived
deconvolution
derived
determination
directed
distribution
dna
dna sequence
electrophoresis
electrophoretic
embodied
encoding
filtering
function
homomorphic
key
limited
means
method
methods
migration
mixture
mixture separated
nucleotide
nucleotide sequence
patterns
peaks
presently
reduce
representing
separated
sequence
set
sharpening
signal
signal peak
signal representing
signals
signals representing
step
steps
technique