Methods and apparatus for analysis of chromatographic migration patterns
Patent
·
OSTI ID:140713
A method and apparatus are presented for sharpening signal peaks in a signal representing the distribution of biological or chemical components of a mixture separated by a chromatographic technique such as, but not limited to, electrophoresis. A key step in the method is the use of a blind deconvolution technique, presently embodied as homomorphic filtering, to reduce the contribution of a blurring function to the signal encoding the peaks of the distribution. The invention further includes steps and apparatus directed to determination of a nucleotide sequence from a set of four such signals representing DNA sequence data derived by electrophoretic means. 16 figures.
- Research Organization:
- University of Utah
- DOE Contract Number:
- FG02-88ER60700
- Assignee:
- Univ. of Utah Research Foundation, Salt Lake City, UT (United States)
- Patent Number(s):
- US 5,273,632/A/
- OSTI ID:
- 140713
- Country of Publication:
- United States
- Language:
- English
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