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Method of measurement in biological systems

Patent ·
OSTI ID:868782
 [1];  [2];  [3];  [4];  [1];  [1]
  1. Livermore, CA
  2. Union City, CA
  3. Danville, CA
  4. Alamo, CA
+ Show Author Affiliations
Disclosed is a method of quantifying molecules in biological substances, comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering said chemical specie to said biological host in doses sufficiently low to avoid significant overt damage to the biological system thereof, d. allowing a period of time to elapse sufficient for dissemination and interaction of said chemical specie with said host throughout said biological system of said host, e. isolating a reacted fraction of the biological substance from said host in a manner sufficient to avoid contamination of said substance from extraneous sources, f. converting said fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in said material by means of direct isotopic counting.
Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA
DOE Contract Number:
W-7405-ENG-48
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 5209919
Application Number:
07/693,248
OSTI ID:
868782
Country of Publication:
United States
Language:
English

References (6)

Applications of Accelerator Mass Spectrometry journal May 1984
Ultrasensitive Mass Spectrometry with Accelerators journal December 1980
Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA. journal July 1990
Memory Effects in an AMS System: Catastrophe and Recovery journal January 1990
Accelerator mass spectrometry in the biomedical sciences: Applications in low-exposure biomedical and environmental dosimetry report May 1990
Ultrasensitive radioisotope, stable-isotope, and trace-element analysis in the biological sciences using tandem accelerator mass spectrometry journal April 1987

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active chemical
administering
allowing
ambient
ambient biosphere
avoid
avoid contamination
avoid significant
biological
biological host
biological substance
biological substances
biological systems
biosphere
charged
chemical
chemical specie
comprising
concentration
concentrations
concentrations equal
contamination
converting
counting
damage
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dissemination
doses
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efficiently
efficiently produces
elapse
elapse sufficient
equal
extraneous
extraneous sources
fraction
fractionation
host
host throughout
interaction
introduction
isolating
isotope concentration
isotopic
isotopic counting
isotopic fractionation
labeled
labeled reactive
long-lived
long-lived radioisotope
manner
manner sufficient
material
means
measurement
measuring
method
molecules
overt
overt damage
period
preparing
produces
produces charged
quantifying
quantifying molecules
radioisotope
radioisotope concentration
radioisotope labeled
radioisotopes
reacted
reacted fraction
reactive
reactive chemical
selecting
significant
significant isotopic
significant overt
sources
specie
substance
substances
sufficient
sufficiently
suitable
suitable means
systems
throughout
time