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Method for detection of long-lived radioisotopes in small biochemical samples

Patent ·
OSTI ID:869613
 [1];  [2];  [3];  [4];  [1]
  1. Livermore, CA
  2. Union City, CA
  3. Danville, CA
  4. Alamo, CA
+ Show Author Affiliations

Disclosed is a method for detection of long-lived radioisotopes in small bio-chemical samples, comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering said chemical specie to said biologist host in doses sufficiently low to avoid significant overt damage to the biological system thereof, d. allowing a period of time to elapse sufficient for dissemination and interaction of said chemical specie with said host throughout said biological system of said host, e. isolating a reacted fraction of the biological substance from said host in a manner sufficient to avoid contamination of said substance from extraneous sources, f. converting said fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in said material by means of direct isotopic counting.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA
DOE Contract Number:
W-7405-ENG-48
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 5366721
OSTI ID:
869613
Country of Publication:
United States
Language:
English

References (3)

Ultrasensitive Mass Spectrometry with Accelerators journal December 1980
Application of AMS to the biomedical sciences journal December 1990
Ultrasensitive radioisotope, stable-isotope, and trace-element analysis in the biological sciences using tandem accelerator mass spectrometry journal April 1987

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