Method of measurement in biological systems
- Livermore, CA
- Union City, CA
- Danville, CA
- Alamo, CA
Disclosed is a method of quantifying molecules in biological substances, comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering said chemical specie to said biological host in doses sufficiently low to avoid significant overt damage to the biological system thereof, d. allowing a period of time to elapse sufficient for dissemination and interaction of said chemical specie with said host throughout said biological system of said host, e. isolating a reacted fraction of the biological substance from said host in a manner sufficient to avoid contamination of said substance from extraneous sources, f. converting said fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in said material by means of direct isotopic counting.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- DOE Contract Number:
- W-7405-ENG-48
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Number(s):
- US 5209919
- Application Number:
- 07/693,248
- OSTI ID:
- 868782
- Country of Publication:
- United States
- Language:
- English
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measurement
biological
systems
disclosed
quantifying
molecules
substances
comprising
selecting
host
radioisotopes
concentrations
equal
ambient
biosphere
preparing
long-lived
radioisotope
labeled
reactive
chemical
specie
administering
doses
sufficiently
avoid
significant
overt
damage
allowing
period
time
elapse
sufficient
dissemination
interaction
throughout
isolating
reacted
fraction
substance
manner
contamination
extraneous
sources
converting
suitable
means
material
efficiently
produces
charged
introduction
isotopic
fractionation
measuring
concentration
direct
counting
reactive chemical
suitable means
avoid contamination
biological substance
biological host
biological systems
chemical specie
reacted fraction
radioisotope labeled
radioisotope concentration
significant isotopic
significant overt
avoid significant
ambient biosphere
produces charged
manner sufficient
isotopic counting
overt damage
concentrations equal
biological substances
isotopic fractionation
long-lived radioisotope
quantifying molecules
extraneous sources
direct isotopic
efficiently produces
elapse sufficient
labeled reactive
doses sufficiently
host throughout
active chemical
isotope concentration
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