Methods for tritium labeling

Andres, Hendrik; Morimoto, Hiromi; Williams, Philip G

Methods for tritium labeling

Patent · Thu Dec 31 23:00:00 EST 1992

OSTI ID:868660

Andres, Hendrik ^[1]; Morimoto, Hiromi ^[2]; Williams, Philip G ^[3]

Hochwald, CH
El Cerrito, CA
Oakland, CA

Reagents and processes for reductively introducing deuterium or tritium into organic molecules are described. The reagents are deuterium or tritium analogs of trialkyl boranes, borane or alkali metal aluminum hydrides. The process involves forming these reagents in situ from alkali metal tritides or deuterides.

View Patent

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA

DOE Contract Number:: AC03-76SF00098

Assignee:: Regents of University of California (Oakland, CA)

Patent Number(s):: US 5186868

OSTI ID:: 868660

Country of Publication:: United States

Language:: English

References (17)

Lithium triethylborohydride. Exceptionally powerful nucleophile in displacement reactions with organic halides Brown, Herbert C.; Krishnamurthy, S. Journal of the American Chemical Society, Vol. 95, Issue 5 https://doi.org/10.1021/ja00786a057	journal	March 1973
The laboratory preparation of lithium deuteride and lithium aluminium deuteride Holding, A. F. le C.; Ross, W. A. Journal of Applied Chemistry, Vol. 8, Issue 5 https://doi.org/10.1002/jctb.5010080508	journal	May 1958
Determination of the specific activity of high specific activity tritium labeled sodium borohydride by tritium nuclear magnetic resonance spectroscopy Altman, Lawrence J.; Thomas, Larry. Analytical Chemistry, Vol. 52, Issue 6 https://doi.org/10.1021/ac50056a053	journal	May 1980
Preparation and use of LiEt3Bt and LiAlT4 at maximum specific activity Andres, Hendrik; Morimoto, Hiromi; Williams, Philip G. Journal of the Chemical Society, Chemical Communications, Issue 8 https://doi.org/10.1039/c39900000627	journal	January 1990
Isotopic exchange of gaseous deuterium with lattice hydrogen of hydrides Nováková, J.; Jírů, P.; Zavadil, V. Collection of Czechoslovak Chemical Communications, Vol. 36, Issue 2 https://doi.org/10.1135/cccc19710520	journal	January 1971
Lithium and potassium trialkylborohydrides. Reagents for direct reduction of .alpha.,.beta.-unsaturated carbonyl compounds to synthetically versatile enolate anions Fortunato, James M.; Ganem, Bruce The Journal of Organic Chemistry, Vol. 41, Issue 12 https://doi.org/10.1021/jo00874a028	journal	June 1976
Representative metalation and reduction reactions of the superactive metal hydrides, LiH, NaH, and KH Pi, Rafael; Friedl, Thomas; Schleyer, Paul v. R. The Journal of Organic Chemistry, Vol. 52, Issue 19 https://doi.org/10.1021/jo00228a027	journal	September 1987
Superactive Alkali Metal Hydride Metalation Reagents: LiH, NaH, and KH Klusener, Peter A. A.; Brandsma, Lambert; Verkruijsse, Hermann D. Angewandte Chemie International Edition in English, Vol. 25, Issue 5 https://doi.org/10.1002/anie.198604651	journal	May 1986
Lithium perhydro-9b-boraphenalylhydride. Active reducing agent of unusually high stereoselectivity for the reduction of cyclic and bicyclic ketones Brown, Herbert Charles; Dickason, William C. Journal of the American Chemical Society, Vol. 92, Issue 3 https://doi.org/10.1021/ja00706a053	journal	February 1970
Lithium triethylborotritide (super-tritide): a useful reagent for tritium labelling Hegde, Shridhar; Coates, Robert M.; Pearce, Cedric J. Journal of the Chemical Society, Chemical Communications, Issue 24 https://doi.org/10.1039/c39830001484	journal	January 1983
REACTIONS OF TRITIUM ATOMS WITH FROZEN CYCLOPROPANE ¹ Moser, H. C.; Shores, R. D. The Journal of Physical Chemistry, Vol. 66, Issue 11 https://doi.org/10.1021/j100817a510	journal	November 1962
Stereospecific synthesis of 1,4-dienes by cross-coupling of allyl halides with alkenylcopper intermediates from alkenyldialkylboranes Brown, Herbert C.; Campbell, James B. The Journal of Organic Chemistry, Vol. 45, Issue 3 https://doi.org/10.1021/jo01291a046	journal	February 1980
Density of trapped gas in heavily-irradiated lithium hydride Bowman, R. C.; Attalla, A.; Souers, P. C. Journal of Nuclear Materials, Vol. 154, Issue 2-3 https://doi.org/10.1016/0022-3115(88)90368-6	journal	July 1988
Addition compounds of alkali metal hydrides. 15. Steric effects in the reaction of representative trialkylboranes with lithium and sodium hydrides to form the corresponding trialkylborohydrides Brown, Herbert C.; Krishnamurthy, S.; Hubbard, John L. Journal of the American Chemical Society, Vol. 100, Issue 11 https://doi.org/10.1021/ja00479a016	journal	May 1978
Tritium nuclear magnetic resonance spectroscopy. 14—analysis of tritiated methyl groups Bloxsidge, James P.; Elvidge, John A.; Jones, John R. Organic Magnetic Resonance, Vol. 15, Issue 2 https://doi.org/10.1002/mrc.1270150220	journal	February 1981
2. The formation of alkali-metal hydrides by atomic hydrogen Ferrell, Edna; Pearson, Thomas G.; Robinson, Percy L. Journal of the Chemical Society (Resumed) https://doi.org/10.1039/jr9340000007	journal	January 1934
Application of modern tritium NMR techniques to analysis of complex isotopic products from a hydrogenation reaction Williams, Philip G.; Morimoto, Hiromi.; Wemmer, David E. Journal of the American Chemical Society, Vol. 110, Issue 24 https://doi.org/10.1021/ja00232a013	journal	November 1988

Similar Records

Preparation of tritium- or deuterium-labeled vitamin D analogs by a convenient general method

Journal Article · Thu Oct 01 00:00:00 EDT 1981 · Proc. Natl. Acad. Sci. U.S.A.; (United States) · OSTI ID:5873760

Direct synthesis of catalyzed hydride compounds

Patent · Tue Sep 21 00:00:00 EDT 2004 · OSTI ID:1175046

SEPARATION OF DEUTERIUM FROM HYDROGEN

Patent · Mon Mar 11 23:00:00 EST 1963 · OSTI ID:4753657

Related Subjects

/252/423/
alkali
alkali metal
aluminum
analogs
borane
boranes
described
deuterides
deuterium
forming
hydrides
introducing
involves
involves forming
labeling
metal
metal aluminum
methods
molecules
organic
organic molecule
organic molecules
process
process involves
processes
reagents
reductively
situ
trialkyl
tritides
tritium
tritium labeling

Methods for tritium labeling

Citation Formats

References (17)

Similar Records

Related Subjects