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Preparation of tritium- or deuterium-labeled vitamin D analogs by a convenient general method

Journal Article · · Proc. Natl. Acad. Sci. U.S.A.; (United States)

The three-step conversion of vitamin D analogs to 6-oxo-3,5-cyclovitamin D derivatives followed by reduction with a tritide or deuteride reagent and subsequent cycloreversion gives 6-tritio(deutero)vitamin D derivatives and corresponding 5,6-trans-analogs. The method is general and affords the 6-labeled-vitamin D analogs in approx. =20% overall yield.

Research Organization:
Univ. of Wisconsin, Madison
OSTI ID:
5873760
Journal Information:
Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 78:10; ISSN PNASA
Country of Publication:
United States
Language:
English

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