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Title: Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use

Abstract

Monoclonal antibodies are described which have specific affinities for halogenated nucleoside analogs and are preferentially selective for one particular halogen. Such antibodies, when incorporated into immunochemical reagents, may be used to identify and independently quantify the cell division character of more than one population or subpopulation in flow cytometric measurements. Independent assessment of division activity in cell sub-populations facilitates selection of appropriate time and dose for administration of anti-proliferative agents. The hybridomas which secrete halogen selective antibodies and the method of making them are described.

Inventors:
 [1];  [2];  [2]
  1. Danville, CA
  2. Livermore, CA
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
OSTI Identifier:
868004
Patent Number(s):
US 5053336
Assignee:
Regents of University of California (Oakland, CA)
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
monoclonal; antibodies; separate; detection; halodeoxyuridines; method; described; specific; affinities; halogenated; nucleoside; analogs; preferentially; selective; particular; halogen; incorporated; immunochemical; reagents; identify; independently; quantify; cell; division; character; population; subpopulation; flow; cytometric; measurements; independent; assessment; activity; sub-populations; facilitates; selection; appropriate; time; dose; administration; anti-proliferative; agents; hybridomas; secrete; monoclonal antibodies; flow cytometric; separate detection; appropriate time; nucleoside analog; chemical reagent; cytometric measurement; chemical reagents; nucleoside analogs; /530/435/

Citation Formats

Vanderlaan, Martin, Watkins, Bruce E, and Stanker, Larry H. Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use. United States: N. p., 1991. Web.
Vanderlaan, Martin, Watkins, Bruce E, & Stanker, Larry H. Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use. United States.
Vanderlaan, Martin, Watkins, Bruce E, and Stanker, Larry H. Tue . "Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use". United States. https://www.osti.gov/servlets/purl/868004.
@article{osti_868004,
title = {Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use},
author = {Vanderlaan, Martin and Watkins, Bruce E and Stanker, Larry H},
abstractNote = {Monoclonal antibodies are described which have specific affinities for halogenated nucleoside analogs and are preferentially selective for one particular halogen. Such antibodies, when incorporated into immunochemical reagents, may be used to identify and independently quantify the cell division character of more than one population or subpopulation in flow cytometric measurements. Independent assessment of division activity in cell sub-populations facilitates selection of appropriate time and dose for administration of anti-proliferative agents. The hybridomas which secrete halogen selective antibodies and the method of making them are described.},
doi = {},
url = {https://www.osti.gov/biblio/868004}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1991},
month = {1}
}

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