Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use
Patent
·
OSTI ID:868004
- Danville, CA
- Livermore, CA
Monoclonal antibodies are described which have specific affinities for halogenated nucleoside analogs and are preferentially selective for one particular halogen. Such antibodies, when incorporated into immunochemical reagents, may be used to identify and independently quantify the cell division character of more than one population or subpopulation in flow cytometric measurements. Independent assessment of division activity in cell sub-populations facilitates selection of appropriate time and dose for administration of anti-proliferative agents. The hybridomas which secrete halogen selective antibodies and the method of making them are described.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA
- DOE Contract Number:
- W-7405-ENG-48
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Number(s):
- US 5053336
- OSTI ID:
- 868004
- Country of Publication:
- United States
- Language:
- English
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affinities
agents
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antibodies
appropriate
appropriate time
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cell
character
chemical reagent
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flow
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halodeoxyuridines
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hybridomas
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sub-populations
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time
activity
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appropriate
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cell
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chemical reagent
chemical reagents
cytometric
cytometric measurement
described
detection
division
dose
facilitates
flow
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halodeoxyuridines
halogen
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hybridomas
identify
immunochemical
incorporated
independent
independently
measurements
method
monoclonal
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nucleoside analogs
particular
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preferentially
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reagents
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separate
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