Combined electrophoretic-separation and electrospray method and system
Patent
·
OSTI ID:867018
- Richland, WA
- Kennewick, WA
A system and method for analyzing molecular constituents of a composition sample includes: forming a solution of the sample, separating the solution by capillary zone electrophoresis into an eluent of constituents longitudinally separated according to their relative electrophoretic mobilities, electrospraying the eluent to form a charged spray in which the molecular constituents have a temporal distribution; and detecting or collecting the separated constituents in accordance with the temporal distribution in the spray. A first high-voltage (e.g., 5-100 KVDC) is applied to the solution. The spray is charged by applying a second high voltage (e.g., .+-.2-8 KVDC) between the eluent at the capillary exit and a cathode spaced in front of the exit. A complete electrical circuit is formed by a conductor which directly contacts the eluent at the capillary exit.
- Research Organization:
- Pacific Northwest National Laboratory (PNNL), Richland, WA
- DOE Contract Number:
- AC06-76RL01830
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Number(s):
- US 4842701
- OSTI ID:
- 867018
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
/204/250/436/
2-8
5-100
accordance
according
analyzing
analyzing molecular
applied
applying
capillary
capillary exit
capillary zone
cathode
cathode spaced
charged
charged spray
circuit
collecting
combined
complete
complete electrical
composition
composition sample
conductor
constituents
constituents longitudinally
contacts
detecting
directly
directly contacts
distribution
electrical
electrical circuit
electrophoresis
electrophoretic
electrophoretic mobilities
electrophoretic-separation
electrospray
electrospraying
eluent
exit
form
formed
forming
front
high-voltage
kvdc
longitudinally
longitudinally separated
method
mobilities
molecular
molecular constituents
relative
relative electrophoretic
sample
separated
separated according
separated constituents
separating
solution
spaced
spray
temporal
temporal distribution
voltage
zone
zone electrophoresis
2-8
5-100
accordance
according
analyzing
analyzing molecular
applied
applying
capillary
capillary exit
capillary zone
cathode
cathode spaced
charged
charged spray
circuit
collecting
combined
complete
complete electrical
composition
composition sample
conductor
constituents
constituents longitudinally
contacts
detecting
directly
directly contacts
distribution
electrical
electrical circuit
electrophoresis
electrophoretic
electrophoretic mobilities
electrophoretic-separation
electrospray
electrospraying
eluent
exit
form
formed
forming
front
high-voltage
kvdc
longitudinally
longitudinally separated
method
mobilities
molecular
molecular constituents
relative
relative electrophoretic
sample
separated
separated according
separated constituents
separating
solution
spaced
spray
temporal
temporal distribution
voltage
zone
zone electrophoresis