Rapid brain scanning radiopharmaceutical

Patent · Wed Dec 31 23:00:00 EST 1986

OSTI ID:866163

Shulgin, Alexander T ^[1]; Mathis, Chester A ^[2]

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1. Lafayette, CA
2. Oakland, CA

A method for detecting the blood flow in animals, particularly in the brain, is provided wherein a detectable amount of a novel radioactive compound of the formula I is administered to one animal: ##STR1## wherein R.sub.1 and R.sub.2 are independently alkyl of 1 to 6 carbon atoms or benzyl; R.sub.3 is alkyl of 1 to 6 carbon atoms, benzyl, cyclopropylalkyl of 4 to 6 carbon atoms, or cyanoalkyl of 2 to 6 carbon atoms; R.sub.4 is hydrogen, benzyl or alkyl of 1 to 6 carbon atoms; with the provisos that R.sub.4 is not isopropyl and when R.sub.4 is methyl, R.sub.3 is not benzyl; and X is a radioactive halogen.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA
• DOE Contract Number: W-7405-ENG-48
• Assignee: Regents of University of California (Berkeley, CA)
• Patent Number(s): US 4647446
• OSTI ID: 866163
• Country of Publication: United States
• Language: English

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benzyl
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blood flow
brain
carbon
carbon atom
carbon atoms
compound
cyanoalkyl
cyclopropylalkyl
detectable
detectable amount
detecting
flow
formula
halogen
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isopropyl
method
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novel
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particularly
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radiopharmaceutical
rapid
rapid brain
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str1