Rapid brain scanning radiopharmaceutical

Patent · Thu Jan 01 00:00:00 EST 1987

OSTI ID:866163

Shulgin, Alexander T ^[1]; Mathis, Chester A ^[2]

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1. Lafayette, CA
2. Oakland, CA

A method for detecting the blood flow in animals, particularly in the brain, is provided wherein a detectable amount of a novel radioactive compound of the formula I is administered to one animal: ##STR1## wherein R.sub.1 and R.sub.2 are independently alkyl of 1 to 6 carbon atoms or benzyl; R.sub.3 is alkyl of 1 to 6 carbon atoms, benzyl, cyclopropylalkyl of 4 to 6 carbon atoms, or cyanoalkyl of 2 to 6 carbon atoms; R.sub.4 is hydrogen, benzyl or alkyl of 1 to 6 carbon atoms; with the provisos that R.sub.4 is not isopropyl and when R.sub.4 is methyl, R.sub.3 is not benzyl; and X is a radioactive halogen.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• DOE Contract Number: W-7405-ENG-48
• Assignee: Regents of University of California (Berkeley, CA)
• Patent Number(s): US 4647446
• OSTI ID: 866163
• Country of Publication: United States
• Language: English

Related Subjects

rapid
brain
scanning
radiopharmaceutical
method
detecting
blood
flow
animals
particularly
provided
detectable
amount
novel
radioactive
compound
formula
administered
animal
str1
independently
alkyl
carbon
atoms
benzyl
cyclopropylalkyl
cyanoalkyl
hydrogen
provisos
isopropyl
methyl
halogen
blood flow
carbon atoms
carbon atom
radioactive compound
active compound
rapid brain
novel radioactive
detectable amount
/424/999/