Complex of transferrin with ruthenium for medical applications

Patent · Tue May 15 00:00:00 EDT 1984

OSTI ID:865008

Richards, Powell ^[1]; Srivastava, Suresh C ^[2]; Meinken, George E ^[3]

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1. Bayport, NY
2. Setauket, NY
3. Middle Island, NY

A novel Ruthenium-transferrin complex, prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40.degree. C. for about 2 hours, and purifying said complex by means of gel chromotography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparative results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex.

• Research Organization: ASSOC UNIVERSITIES INC
• DOE Contract Number: AC02-76CH00016
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4448762
• Application Number: 06/203,194
• OSTI ID: 865008
• Country of Publication: United States
• Language: English

Related Subjects

/424/530/
40
abscesses
acetate
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agent
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chromotography
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complex
degree
detection
di-metal
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dissolved
eluent
ga-67-citrate
heating
hours
human
increased
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iron-free
means
medical
medical applications
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metal complex
mono-
novel
nuclear
nuclear medicine
ph
prepared
produced
purifying
reacting
results
ru-transferrin
ruthenium
ruthenium-transferrin
sensitivity
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solution
transferrin
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tumor
tumor uptake
tumor-localizing
tumors
uptake
widely