Complex of transferrin with ruthenium for medical applications. [Ru 97, Ru 103]

Patent · Sun Nov 02 23:00:00 EST 1980

OSTI ID:5176384

Richards, P; Srivastava, S C; Meinken, G E

A novel Ruthenium-transferrin complex, prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40/sup 0/C for about 2 hours, and purifying said complex by means of gel chromatography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparitive results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex.

• DOE Contract Number: EY-76-C-02-0016
• Assignee: Dept. of Energy
• Patent Number(s): None
• OSTI ID: 5176384
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
CARBOXYLIC ACID ESTERS
CHEMICAL PREPARATION
CITRIC ACID ESTERS
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
EVEN-ODD NUCLEI
GALLIUM 67
GALLIUM ISOTOPES
GLOBULINS
GLOBULINS-BETA
IMPLANTS
INFLAMMATION
INTERMEDIATE MASS NUCLEI
INTERNAL IRRADIATION
IRRADIATION
ISOTOPES
LABELLED COMPOUNDS
LABELLING
METALLOPROTEINS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PROTEINS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RUTHENIUM 103
RUTHENIUM 97
RUTHENIUM ISOTOPES
SYMPTOMS
SYNTHESIS
TRANSFERRIN
USES