Complex of transferrin with ruthenium for medical applications

Patent · Tue May 15 00:00:00 EDT 1984

OSTI ID:7242911

Richards, P; Srivastava, S C; Meinken, G E

A novel ruthenium-transferrin complex is disclosed which is prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40 C for about 2 hours. The complex is purified by means of gel chromotography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparative results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex. No Drawings

• DOE Contract Number: AC02-76CH00016
• Assignee: Dept. of Energy, Washington, DC (United States)
• Patent Number(s): US 4448762; A
• Application Number: PPN: US 6-203194
• OSTI ID: 7242911
• Resource Relation: Patent File Date: 3 Nov 1980
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GALLIUM 67
UPTAKE
RUTHENIUM
DIAGNOSTIC USES
TRANSFERRIN
BETA DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
GALLIUM ISOTOPES
GLOBULINS
GLOBULINS-BETA
INTERMEDIATE MASS NUCLEI
ISOTOPES
METALLOPROTEINS
METALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PLATINUM METALS
PROTEINS
RADIOISOTOPES
TRANSITION ELEMENTS
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics