Cholinesterase inhibitor soman increases inositol trisphosphate in rat brain. (Reannouncement with new availability information)
Technical Report
·
OSTI ID:80538
Studies were conducted to determine the effect of the cholinesterase inhibitor soman on the amount of inositol trisphosphate in the neocortex, striatum, cerebellum, and medulla-pons regions of rat brain in vivo. The studies indicate that treatment with soman increase inositol trisphosphate in the neocortex and striatum, but not in the cerebellum or medulla-pons region. In the neocortex the most pronounced increases were observed in animals with severe poisoning symptoms; however, inositol trisphophate was also found to be elevated in animals with only mild poisoning symptoms. A variety of evidence suggests that the receptor-mediated hydrolysis of phosphatidyl inositol results in the formation of inositol trisphosphate (IP3) and diacylglycerol, both of which function as intracellular signal messengers, and that this mechanism represents a major signal transduction system through which extracellular signals can influence intracellular events.
- Research Organization:
- Texas Univ. Health Science Center, San Antonio, TX (United States). Dept. of Pharmacology
- OSTI ID:
- 80538
- Report Number(s):
- AD-A--234712/8/XAB; CNN: Contract DAMD17-85-C-5135
- Country of Publication:
- United States
- Language:
- English
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