Cholinesterase inhibitor soman increases inositol trisphosphate in rat brain. (Reannouncement with new availability information)
Studies were conducted to determine the effect of the cholinesterase inhibitor soman on the amount of inositol trisphosphate in the neocortex, striatum, cerebellum, and medulla-pons regions of rat brain in vivo. The studies indicate that treatment with soman increase inositol trisphosphate in the neocortex and striatum, but not in the cerebellum or medulla-pons region. In the neocortex the most pronounced increases were observed in animals with severe poisoning symptoms; however, inositol trisphophate was also found to be elevated in animals with only mild poisoning symptoms. A variety of evidence suggests that the receptor-mediated hydrolysis of phosphatidyl inositol results in the formation of inositol trisphosphate (IP3) and diacylglycerol, both of which function as intracellular signal messengers, and that this mechanism represents a major signal transduction system through which extracellular signals can influence intracellular events.
- Research Organization:
- Texas Univ. Health Science Center, San Antonio, TX (United States). Dept. of Pharmacology
- OSTI ID:
- 80538
- Report Number(s):
- AD-A--234712/8/XAB; CNN: Contract DAMD17-85-C-5135
- Country of Publication:
- United States
- Language:
- English
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