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Formation and actions of calcium-mobilizing messenger, inositol 1,4,5-trisphosphate

Journal Article · · Am. J. Physiol.; (United States)
OSTI ID:6285084
A variety of surface membrane receptors can activate a phospholipase C, which degrades phosphatidylinositol 4,5-bisphosphate liberating a calcium mobilizing second messenger, inositol 1,4,5-trisphosphate ((1,4,5)IP3). The coupling of surface receptors to the phospholipase C involves one or more quanine nucleotide-dependent regulatory proteins that are similar but not identical to those that regulate adenylate cyclase. (1,4,5)IP3 has been shown to release CaS from a portion of the endoplasmic reticulum and is believed responsible for the initial phase of CaS mobilization ascribed to internal CaS release. (1,4,5)IP3 acts by binding to a specific receptor that either is a component of, or regulates, a CaS ion channel. The release of CaS from the (1,4,5)IP3-sensitive component of the endoplasmic reticulum may secondarily activate the second phase of CaS mobilization, which involves CaS entry. (1,4,5)IP3 is metabolized by two pathways. One involves the action of a 5-phosphatase that degrades (1,4,5)IP3 to inositol 1,4-bisphosphate, whereas the other involves a 3-kinase that phosphorylates (1,4,5)IP3 to produce inositol 1,3,4,5-tetrakisphosphate. The significance of this dual metabolism is not known, but it may be important in rapidly extinguishing the CaS -releasing activity (1,4,5)IP3.
OSTI ID:
6285084
Journal Information:
Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:2; ISSN AJPHA
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
ANIMAL CELLS
ANIMALS
ATP
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIODEGRADATION
CALCIUM 45
CALCIUM COMPOUNDS
CALCIUM ISOTOPES
CARBOHYDRATES
CARBOXYLESTERASES
CATIONS
CELL CONSTITUENTS
CELL MEMBRANES
CHARGED PARTICLES
CHEMICAL ACTIVATION
CHEMICAL REACTIONS
DAYS LIVING RADIOISOTOPES
DECOMPOSITION
ENDOPLASMIC RETICULUM
ENZYME INDUCTION
ENZYMES
ESTERASES
EVEN-ODD NUCLEI
GENE REGULATION
GUINEA PIGS
HYDROLASES
INOSITOLS
INTERMEDIATE MASS NUCLEI
IONS
ISOTOPES
LIPASE
LIVER CELLS
MAMMALS
MEMBRANES
MONOSACCHARIDES
NUCLEI
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANOIDS
RADIOISOTOPES
RECEPTORS
RODENTS
SACCHARIDES
SOMATIC CELLS
UPTAKE
VERTEBRATES