Boron neutron capture therapy of malignant melanoma using {sup 10}B-paraboronophenylalanine with special reference to evaluation of radiation dose and damage to the normal skin
- Tohoku Univ., Sendai (Japan)
- Kawasaki Medical School, Kurashiki (Japan)
- Kobe Univ. School of Medicine (Japan)
- Kyoto Univ. Research Reactor Institute, Kumatori (Japan)
- Shinsyu Univ., Matsumoto (Japan)
- Hyogo Medical Center, Akashi (Japan); and others
A treatment regimen for boron neutron capture therapy of malignant melanomas is described using {sup 10}B-paraboronophenylalanine as the tumor-targeting compound. As a therapeutic dose, we adopted the maximum tolerable dose for the skin regardless of tumor {sup 10}B concentration. In practice, the maximum neutron fluence should be decided prior to starting irradiation. For this purpose, the kinetics of the concentration of {sup 10}B in the blood and skin and the skin-to-blood ratios were analyzed in the six patients who received 170 mg/kg of the compound intravenously, and skin concentrations during irradiation were predicted using a standard skin factor curve. This yields a skin concentration at time T based on the blood concentration at time 0. We calculated the maximum tolerable fluence yielding but not exceeding 18 RBE-Gy by assuming that the RBE of {sup 14}N(n,p){sup 14}C and {sup 10}B(n,{alpha}){sup 7}Li reaction for skin damage is 2.5. Actual skin reactions in three of five patients treated with the therapy were, as predicted, within tolerable limits, and we were able to obtain complete tumor regression in four cases. The results indicate that application of our logical approach will be useful for subsequent cases and further development of this therapy. 23 refs., 5 figs., 5 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 79322
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 3 Vol. 138; ISSN RAREAE; ISSN 0033-7587
- Country of Publication:
- United States
- Language:
- English
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