RBEs of thermal neutron capture therapy and 10B(n, alpha)7 Li reaction on melanoma-bearing hamsters

Journal Article · Sat Jul 01 04:00:00 EDT 1989 · Pigment Cell Research; (USA)

DOI:https://doi.org/10.1111/j.1600-0749.1989.tb00219.x· OSTI ID:5184850

Hiratsuka, J; Kono, M; Mishima, Y ^[1]

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1. Kobe Univ. School of Medicine (Japan)

Using Greene's melanoma transplanted into Syrian (golden) hamsters, we determined the relative biological effectiveness (RBE) of thermal neutron capture therapy (TNCT) using 10B-paraboronophenylalanine (10B-BPA) in comparison with a 9-MeV electron beam. We also obtained the RBE of the 10B(n, alpha)7 Li reaction by calculation based on summed dose data from TNCT. Throughout this study, the Kyoto University Research Reactor was used as the source for thermal neutrons; the reactor was specially altered to attain a low contamination level both for gamma-rays and fast neutrons. 10B-BPA was administered 8 hours before thermal neutron irradiation to the hamsters with melanoma. The tumor was then irradiated at 5 MW for 90 minutes. The absorbed dose from this TNCT was calculated by the method of Fairchild and Goodman. The RBEs of the TNCT and the 10B(n, alpha)7 Li reaction obtained by the tumor growth delay time (TGDT) method were 2.22 and 2.51, respectively, at 10.5 days of TGDT. These RBE values varied with TGDT and the absorbed dose. The RBE value of TNCT had a peak at 7.0 days of TGDT; that of the 10B(n, alpha)7Li reaction was higher at a low absorbed dose level and lower at a high absorbed dose level.

• OSTI ID: 5184850
• Journal Information: Pigment Cell Research; (USA), Journal Name: Pigment Cell Research; (USA) Vol. 2:4; ISSN 0893-5785; ISSN PCREE
• Country of Publication: United States
• Language: English

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550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
AMINO ACIDS
ANIMALS
BARYONS
BEAMS
BORON 10
BORON ISOTOPES
CARBOXYLIC ACIDS
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
ELECTRON BEAMS
ELEMENTARY PARTICLES
EXPERIMENTAL NEOPLASMS
FAST NEUTRONS
FERMIONS
GAMMA RADIATION
HADRONS
HAMSTERS
IONIZING RADIATIONS
ISOTOPES
LEPTON BEAMS
LIGHT NUCLEI
LITHIUM 7
LITHIUM ISOTOPES
MAMMALS
MEDICINE
MELANOMAS
NEOPLASMS
NEUTRON BEAMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NEUTRONS
NUCLEAR MEDICINE
NUCLEI
NUCLEON BEAMS
NUCLEONS
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PARTICLE BEAMS
PHENYLALANINE
RADIATION DOSES
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RBE
RODENTS
STABLE ISOTOPES
THERAPY
VERTEBRATES