Estimation of absorbed dose in the covering skin of human melanoma treated by neutron capture therapy

Journal Article · Sat Jul 01 04:00:00 EDT 1989 · Pigment Cell Research; (USA)

DOI:https://doi.org/10.1111/j.1600-0749.1989.tb00222.x· OSTI ID:5157605

Fukuda, H; Kobayashi, T; Hiratsuka, J; Karashima, H; Honda, C; Yamamura, K; Ichihashi, M; Kanda, K; Mishima, Y ^[1]

---

1. National Institute of Radiological Sciences, Chiba (Japan)

A patient with malignant melanoma was treated by thermal neutron capture therapy using 10B-paraboronophenylalanine. The compound was injected subcutaneously into ten locations in the tumor-surrounding skin, and the patient was then irradiated with thermal neutrons from the Musashi Reactor at reactor power of 100 KW and neutron flux of 1.2 X 10(9) n/cm{sup 2}/s. Total absorbed dose to the skin was 11.7-12.5 Gy in the radiation field. The dose equivalents of these doses were estimated as 21.5 and 24.4 Sv, respectively. Early skin reaction after irradiation was checked from day 1 to day 60. The maximum and mean skin scores were 2.0 and 1.5, respectively, and the therapy was safely completed as far as skin reaction was concerned. Some factors influencing the absorbed dose and dose equivalent to the skin are discussed.

• OSTI ID: 5157605
• Journal Information: Pigment Cell Research; (USA), Journal Name: Pigment Cell Research; (USA) Vol. 2:4; ISSN 0893-5785; ISSN PCREE
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BODY
CARBOXYLIC ACIDS
DISEASES
DOSE EQUIVALENTS
DOSE-RESPONSE RELATIONSHIPS
DOSES
INJECTION
INTAKE
MEDICINE
MELANOMAS
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PHENYLALANINE
RADIATION DOSES
RADIOLOGY
RADIOTHERAPY
SKIN
SUBCUTANEOUS INJECTION
THERAPY