New thermal neutron capture therapy for malignant melanoma: melanogenesis-seeking 10B molecule-melanoma cell interaction from in vitro to first clinical trial

Journal Article · Sat Jul 01 04:00:00 EDT 1989 · Pigment Cell Research; (USA)

DOI:https://doi.org/10.1111/j.1600-0749.1989.tb00196.x· OSTI ID:5157713

Mishima, Y; Ichihashi, M; Hatta, S; Honda, C; Yamamura, K; Nakagawa, T ^[1]

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1. Kobe Univ. School of Medicine (Japan)

Human melanoma regression by single thermal neutron capture therapy (NCT) using melanoma-seeking 10B compounds has been achieved. Since 1972, the aim of my team has been to synthesize tumor-seeking 10B-compounds possessing selective affinity for specific metabolic activity of the target cancer cells. Once the melanoma takes up these 10B compounds, thermal neutrons, which cause insignificant cell damage, are easily absorbed by nonradioactive 10B, inducing the 10B(n, alpha)7Li reaction and releasing the high LET particles to 14 mu melanoma cell diameter, destroying the tumor without damaging surrounding tissue. Radiobiological and preclinical studies culminated in the first successful human NCT treatment, with no recurrence of the treated melanoma since July, 1987.23 references.

• OSTI ID: 5157713
• Journal Information: Pigment Cell Research; (USA), Journal Name: Pigment Cell Research; (USA) Vol. 2:4; ISSN 0893-5785; ISSN PCREE
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
ANIMALS
BEAMS
BORON 10
BORON ISOTOPES
DISEASES
DOCUMENT TYPES
ENERGY TRANSFER
ISOTOPES
LET
LIGHT NUCLEI
LITHIUM 7
LITHIUM ISOTOPES
MAMMALS
MAN
MEDICINE
MELANOMAS
NEOPLASMS
NEUTRON BEAMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
NUCLEON BEAMS
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
PARTICLE BEAMS
PRIMATES
RADIOLOGY
RADIOTHERAPY
REVIEWS
STABLE ISOTOPES
THERAPY
VERTEBRATES