Specific killing effect of 10B1-para-boronophenylalanine in thermal neutron capture therapy of malignant melanoma: in vitro radiobiological evaluation

Journal Article · Mon Mar 01 04:00:00 EST 1982 · J. Invest. Dermatol.; (United States)

DOI:https://doi.org/10.1111/1523-1747.ep12506489· OSTI ID:5465258

Ichihashi, M; Nakanishi, T; Mishima, Y

A 10B-dopa analogue, 10B1-para-boronophenylalanine (10B1-BPA) has been found to have a marked melanoma killing effect as expressed by the Do value, 0.9-1.2 X 10(12) n/cm2. The Do value of the neutron alone is 2.8 X 10(12) n/cm2. After the introduction of high LET irradiation into radiotherapy, its higher energy deposition in the target cancer cells is one of the major problems currently to be solved. This can be achieved by our thermal neutron capture therapy in the order of cellular dimensions when we have highly tumor-seeking 10B-compounds available. Our present evidence seems to indicate that our new 10B1-BPA can highly concentrate 10B into melanoma cells, to as much as 11 times the level of the medium in the in vitro system.

• Research Organization: Department of Dermatology, Kobe University School of Medicine, Japan
• OSTI ID: 5465258
• Journal Information: J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 78:3; ISSN JIDEA
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BARYONS
BIOLOGY
CELL KILLING
DISEASES
ELEMENTARY PARTICLES
FERMIONS
HADRONS
IN VITRO
MEDICINE
MELANOMAS
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NEUTRONS
NUCLEAR MEDICINE
NUCLEONS
ORGANIC BORON COMPOUNDS
ORGANIC COMPOUNDS
RADIOBIOLOGY
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
THERAPY
THERMAL NEUTRONS
TUMOR CELLS