PRODUCTION OF RADIOACTIVE IODINE.

Conference · Wed Aug 08 04:00:00 EDT 2001

OSTI ID:787626

SCHLYER, D J ^[1]

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1. BROOKHAVEN NATIONAL LABORATORY

Probably the most widely used cyclotron produced radiohalogen is I-123. It has gradually replaced I-131 as the isotope of choice for diagnostic radiopharmaceuticals containing radioiodine. It gives a much lower radiation dose to the patient and the gamma ray energy of 159 keV is ideally suited for use in a gamma camera. The gamma ray will penetrate tissue very effectively without excessive radiation dose. For this reason, it has in many instances replaced the reactor produced iodine-131 (Lambrecht and Wolf 1973). A great number of radiopharmaceuticals have been labeled using I-123 and the number is increasing. One of the most promising uses of I-123 is in the imaging of monoclonal antibodies to localize and visualize tumors. However, preclinical and clinical experiences with radiolabeled antibodies have not realized the expectations regarding specificity and sensitivity of tumor localization with these agents. It appears that much of the administered activity is not associated with the tumor site and only a small fraction actually accumulates there. Work continues in this area and tumor-associated antigens can be targets for specific antibody reagents.

• Research Organization: Brookhaven National Lab., Upton, NY (US)
• Sponsoring Organization: USDOE Office of Energy Research (ER) (US)
• DOE Contract Number: AC02-98CH10886
• OSTI ID: 787626
• Report Number(s): BNL--68599; KP140102; KP140102
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GAMMA CAMERAS
IODINE 123
ISOTOPE PRODUCTION
MONOCLONAL ANTIBODIES
NEOPLASMS
RADIATION DOSES
RADIOPHARMACEUTICALS