Monoclonal antibodies: potential role in radiation therapy and oncology
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Specificity, which is a hallmark of the immune system, will be used in radiation oncology in both diagnosis and therapy through the application of radiolabelled monoclonal and polyclonal antibodies. Antigenic specificities, antibody preparations, and the tumor as a target for radiolabelled antibody is reviewed. Several clinical situations, i.e. single tumor cell suspensions, intraperitoneal single cells and masses, and solid tumors are reviewed in regard to both immune antibody targeting and specific differences between tumors in these regions. The concentration of tumor associated antigens is introductory to radiolabelled antibodies in diagnosis. In the radiation therapy of solid tumors, data regarding tumor dose, tumor effective half-life, varied antibody preparations, and the use of radiolabelled antibody as a method of tumor implantation is discussed using antiferritin /sup 131/I-IgG as a model in hepatoma. The theoretical applications of monoclonal antibody integrated in cancer therapy are then presented as a new goal for future development.
- Research Organization:
- John Hopkins Comprehensive Cancer Center, Baltimore, MD
- OSTI ID:
- 6707906
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:7; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
COMPLEXES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DOCUMENT TYPES
FERRITIN
GLOBULINS
HEPATOMAS
IMMUNOGLOBULINS
IMMUNOLOGY
IMMUNOTHERAPY
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
IRON COMPLEXES
ISOTOPES
MEDICINE
METALLOPROTEINS
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOIMMUNOLOGY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
REVIEWS
THERAPY
TRANSITION ELEMENT COMPLEXES
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
COMPLEXES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DOCUMENT TYPES
FERRITIN
GLOBULINS
HEPATOMAS
IMMUNOGLOBULINS
IMMUNOLOGY
IMMUNOTHERAPY
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
IRON COMPLEXES
ISOTOPES
MEDICINE
METALLOPROTEINS
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOIMMUNOLOGY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
REVIEWS
THERAPY
TRANSITION ELEMENT COMPLEXES