Multipoint interval mapping of quantitative trait loci, using sib pairs

Journal Article · Mon May 01 04:00:00 EDT 1995 · American Journal of Human Genetics

OSTI ID:75459

Fulker, D W; Cherny, S S ^[1]; Cardon, L R ^[2]

---

1. Univ. of Colorado, Boulder (United States)
2. Stanford Univ., Menlo Park, CA (United States)

The sib-pair interval-mapping procedure of Fulker and Cardon is extended to take account of all available marker information on a chromosome simultaneously. The method provides a computationally fast multipoint analysis of sib-pair data, using a modified Haseman-Elston approach. It gives results very similar to those of the earlier interval-mapping procedure when marker information is relatively uniform and a coarse map is used. However, there is substantial improvement over the original method when markers differ in information content and/or when a dense map is employed. The method is illustrated by using simulated sib-pair data. 14 refs., 4 figs., 2 tabs.

• OSTI ID: 75459
• Journal Information: American Journal of Human Genetics, Journal Name: American Journal of Human Genetics Journal Issue: 5 Vol. 56; ISSN 0002-9297; ISSN AJHGAG
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
99 GENERAL AND MISCELLANEOUS
BIOLOGICAL MARKERS
CALCULATION METHODS
GENES
GENETIC MAPPING
GENETICS
HUMAN CHROMOSOMES
MATHEMATICAL MODELS
RESOLUTION