A sib-pair approach to interval mapping a quantitative trait loci

Journal Article · Wed Jun 01 04:00:00 EDT 1994 · American Journal of Human Genetics; (United States)

OSTI ID:7075783

Fulker, K W ^[1]; Cardon, L R ^[2]

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1. Univ. of Colorado, Boulder (United States)
2. Stanford Univ., CA (United States)

An interval mapping procedure based on the sib-pair method of Haseman and Elston is developed, and simulation studies are carried out to explore its properties. The procedure is analogous to other interval mapping procedures used with experimental material, such as plants and animals, and yields very similar results in terms of the location and effects size of a quantitative trait locus (QTL). The procedure offers an advantage over the conventional Haseman and Elston approach, in terms of power, and provides useful information concerning the location of a QTL. Because of its simplicity, the method readily lends itself to the analysis of selected samples for increased power and the evaluation of multilocus models of complex phenotypes. 26 refs., 4 figs., 5 tabs.

• OSTI ID: 7075783
• Journal Information: American Journal of Human Genetics; (United States), Journal Name: American Journal of Human Genetics; (United States) Vol. 54:6; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS
990200 -- Mathematics & Computers
BIOLOGICAL MARKERS
GENETIC MAPPING
MAPPING
MATHEMATICAL MODELS
STATISTICAL MODELS