The power of interval mapping of quantitative trait loci, using selected sib pairs

Journal Article · Sat Oct 01 04:00:00 EDT 1994 · American Journal of Human Genetics

OSTI ID:35511

Cardon, L R ^[1]; Fulker, D W ^[2]

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1. Stanford Univ., CA (United States)
2. Univ. of Colorado, Boulder, CO (United States)

The interval-mapping procedure of Fulker and Cardon for analysis of a quantitative-trait loci (QTL) is extended for application to selected samples of sib pairs. Phenotypic selection of sib pairs, which is known to yield striking increases in power when a single marker is used, provides further increases in power when the interval-mapping approach is used. The greatest benefits of the combined approach are apparent with coarse maps, where QTLs of relatively modest (15%-20%) heritability can be detected with widely spaced markers (40-60 cM apart) in reasonably sized sibling samples. Useful information concerning QTL location is afforded by interval mapping in both selected and unselected samples. 12 refs., 3 figs., 2 tabs.

• OSTI ID: 35511
• Journal Information: American Journal of Human Genetics, Journal Name: American Journal of Human Genetics Journal Issue: 4 Vol. 55; ISSN 0002-9297; ISSN AJHGAG
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENETIC MAPPING
HEREDITARY DISEASES
HUMAN CHROMOSOMES
HUMAN POPULATIONS
PHENOTYPE
RFLPS