Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Transplantation of hematopoietic and lymphoid cells in mice. [X radiation]

Journal Article · · Transplantation; (United States)
OSTI ID:7364211
; ; ; ;
CBA mice were exposed to a supralethal dose of whole body x-irradiation and received transplants of graded, small doses of bone marrow, fetal liver, or fetal liver plus fetal thymus cells obtained from H-2 matched C58 or H-2 mismatched A donors. Survival at 20 days was used to evaluate the ability of the transplants to restore hematopoiesis following the acute radiation injury. In the higher dose ranges of 6 x 10/sup 7/ and 1.2 x 10/sup 8/ cells/kg body weight, the fetal cells were as effective as adult bone marrow in both the matched and mismatched strain combinations. Survival at 100 days was used to evaluate the severity of chronic graft-versus-host disease produced by each of the transplants. In the higher dose ranges, cells from fetal donors promoted higher long-term survival rates than did comparable doses of bone marrow cells in both the matched and mismatched strain combinations. The most important finding was that cells from mismatched unrelated fetal donors (using a cell dose per kilogram body weight comparable to the number of fetal liver and thymus cells which would be obtainable from one human fetus at 14 weeks of embryonation) promoted higher long-term survival rates than did bone marrow transplants from matched unrelated donors.
Research Organization:
Mount Sinai Medical Center, Milwaukee
OSTI ID:
7364211
Journal Information:
Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 21:4; ISSN TRPLA
Country of Publication:
United States
Language:
English

Similar Records

Graft versus host inhibition. IX. Therapeutic potential of combined fetal liver and thymus cells as a universal hematopoietic stem cell source for transplantation. Final report 1 Mar 72--31 Jul 77
Technical Report · Tue Jan 17 23:00:00 EST 1978 · OSTI ID:7086128
Proliferation of Donor Thymus Cells in the Bone Marrow and Spleen of Irradiated Syngeneic Host Mice
Journal Article · Fri Nov 30 23:00:00 EST 1973 · Radiation Research · OSTI ID:4336946
Tolerance, immunocompetence, and secondary disease in fully allogeneic radiation chimeras
Journal Article · Mon Aug 01 00:00:00 EDT 1983 · Transplantation; (United States) · OSTI ID:5545355

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
GLANDS
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
INJURIES
IONIZING RADIATIONS
LEUKOCYTES
LIVER
LYMPHOCYTES
MAMMALS
MICE
ORGANS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RODENTS
SOMATIC CELLS
SURVIVAL TIME
THYMOCYTES
TISSUES
TRANSPLANTS
VERTEBRATES
X RADIATION