Proliferation of Donor Thymus Cells in the Bone Marrow and Spleen of Irradiated Syngeneic Host Mice
When CBA/H mice were irradiated with 600 R, and injected with 5 x l0⁷ CBA/HT₆T₆ thymus cells, donor thydue cells comprised nearly l00% of the dividing population in the host lymph nodes and spleen, and more than 70% in the bone marrow on day 5, respectively. The percentages of dividing donor thymus cells quickly declined in the bone marrow and spleen, reaching less than 5% by day 20. When CBA/H mice were irradiated with 600 R, and injected with 1 x 10⁷ CBA/H bone marrow cells plus 5 x 10⁷1 CBA/ H₆T₆ thymus cells, or 1 x 10⁷ CBA/HT₆T₆ marrow cel ls plus 5 x 10/ sup 7/ CBA/H thymus cells, donor marrow cells comprised more than 50% of the dividing cell population in the bone marrow and spleen on day 5, nearly 100% by day 20. The division of donor thymus cells in the bone marrow was totally suppressed after the injection of marrow and thymus cells. The numbers of dividing cells of donor thymus origin were far smaller in the bone marrow and spleen of mice injected with marrow and thymus cells than in those of mice injected with thymus cells. The time courses of the percentages of dividing donor thymus cells in the thymus were hardly influenced by the simultaneous injection of marrow cells. In conclusion, the thymus has cells capable of repopulating the bone marrow and spleen of irradiated host mice, but the proliferation of donor thymus cells in the bone marrow and spleen is suppressed if marrow cells are injected together with thymus cells. (auth)
- Research Organization:
- Roswell Park Memorial Inst., Springville, NY
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-29-016009
- OSTI ID:
- 4336946
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 3 Vol. 56; ISSN 0033-7587
- Publisher:
- Radiation Research Society
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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