Graft versus host inhibition. IX. Therapeutic potential of combined fetal liver and thymus cells as a universal hematopoietic stem cell source for transplantation. Final report 1 Mar 72--31 Jul 77
Technical Report
·
OSTI ID:7086128
The major accomplishment under this contract was the development and testing of a treatment model using mice to evaluate transplantation of liver and thymus cells from immunologically immature (fetal) donors as a source of hematopoietic stem cells. The following observations were made: (1) Fetal liver cells can be used as a source of hematopoietic stem cells without the complication of acute graft-versus-host disease; (2) Recovery from radiation injury was dependent on the dose of fetal liver cells transplanted; (3) Transplanting very small numbers of fetal thymus cells, in addition to liver cells, had a significant and salutary effect on recovery from radiation injury in some strain combinations, but not in others; (4) Transplantation of fetal liver cells from histoincompatible unrelated donors resulted in less delayed secondary disease mortality than did bone marrow transplants from histocompatible unrelated donors; (5) Cell yields from human embryonic tissue increased exponentially with age, and the liver:thymus ratio was 35.4:1, and (6) Fetal liver + or - thymus cells promoted recovery in lethally irradiated adult mice when given in a cell dose per kg body weight comparable to that from a human fetus at 14 weeks embryonation.
- Research Organization:
- Mount Sinai Medical Center, Milwaukee, WI (USA). Winter Research Lab.
- OSTI ID:
- 7086128
- Report Number(s):
- AD-A-049151
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BLOOD FORMATION
BODY
DIGESTIVE SYSTEM
EXTERNAL IRRADIATION
FETUSES
GLANDS
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
IMMUNOLOGY
INHIBITION
IONIZING RADIATIONS
IRRADIATION
LETHAL IRRADIATION
LIVER
LYMPHATIC SYSTEM
MAMMALS
MICE
ORGANS
POST-IRRADIATION THERAPY
RADIATION EFFECTS
RADIATIONS
RECOVERY
RODENTS
SOMATIC CELLS
STEM CELLS
THERAPY
THYMUS
TRANSPLANTS
VERTEBRATES
WHOLE-BODY IRRADIATION
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BLOOD FORMATION
BODY
DIGESTIVE SYSTEM
EXTERNAL IRRADIATION
FETUSES
GLANDS
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
IMMUNOLOGY
INHIBITION
IONIZING RADIATIONS
IRRADIATION
LETHAL IRRADIATION
LIVER
LYMPHATIC SYSTEM
MAMMALS
MICE
ORGANS
POST-IRRADIATION THERAPY
RADIATION EFFECTS
RADIATIONS
RECOVERY
RODENTS
SOMATIC CELLS
STEM CELLS
THERAPY
THYMUS
TRANSPLANTS
VERTEBRATES
WHOLE-BODY IRRADIATION