Tritium incorporation at specific positions in benzo(a)pyrene
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
The carcinogen, benzo(a)pyrene, was tritiated by two methods: exchange reaction with T/sub 2/SO/sub 4/ at the 1, 3 and 6 positions and quenching of a Grignard reagent prepared from 6-iodo-benzo(a)pyrene with T/sub 2/O which gave almost exclusively 6-tritiated material. The exchange reaction incorporated 118 mCi/mmole of which 60 percent was determined to be in the 6 position and 40 percent in the 1 and 3 positions. The Grignard reaction produced a specific activity of 56 mCi/mmole of which 97.5 percent was incorporated in the 6 position.
- Research Organization:
- Univ. of California, Berkeley
- OSTI ID:
- 7362525
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 63:3; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400303 -- Organic Chemistry-- Isotope Exchange & Isotope Separation-- (-1987)
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
AROMATICS
BENZOPYRENE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL PREPARATION
CHEMICAL REACTIONS
CONDENSED AROMATICS
HYDROCARBONS
HYDROGEN ISOTOPES
ISOTOPES
ISOTOPIC EXCHANGE
LABELLED COMPOUNDS
LIGHT NUCLEI
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
SYNTHESIS
TRITIUM
TRITIUM COMPOUNDS
YEARS LIVING RADIOISOTOPES
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400303 -- Organic Chemistry-- Isotope Exchange & Isotope Separation-- (-1987)
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
AROMATICS
BENZOPYRENE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL PREPARATION
CHEMICAL REACTIONS
CONDENSED AROMATICS
HYDROCARBONS
HYDROGEN ISOTOPES
ISOTOPES
ISOTOPIC EXCHANGE
LABELLED COMPOUNDS
LIGHT NUCLEI
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
SYNTHESIS
TRITIUM
TRITIUM COMPOUNDS
YEARS LIVING RADIOISOTOPES